These drugs release endorphins not dopamine.
Dopamine is not a feel-good neurotransmitter.
It’s widely misunderstood and misapplied.
Thank me later...
Submitted 2 weeks ago by lemmydividebyzero@reddthat.com to [deleted]
https://reddthat.com/pictrs/image/23ab8adf-794f-418a-aa9d-4ee816630a4f.png
Comments
daannii@lemmy.world 2 weeks ago
Amir@lemmy.ml 2 weeks ago
Isn’t dopamine causing the “yes I successfully did it” feeling too?
daannii@lemmy.world 2 weeks ago
Nope.
That’s endorphins.
icelimit@lemmy.ml 2 weeks ago
So. How much endorphins does meth give relative to other stuff on the chart?
daannii@lemmy.world 2 weeks ago
That depends on two things.
The dosage and the person’s tolerance.
Drugs that are ranked higher for drug addiction typically have strong fast effects and fast loss of the high.
But all drugs have addiction capabilities because of how tolerance in the body works. Tolerance, withdrawal, addiction. All part of the same process.
So back to addiction.
Cocaine. Immediate and intense high. But doesnt last that long. Same for the heroine.
Drugs like meth and adderall are basically exactly like cocaine in many ways except the high is actually more mild (per dose) and lasts longer.
Opiate medications can be seen as similar to heroine but. Last longer and not as strong.
Of course you can take larger doses of either of those two and get a stronger effect.
Even if you don’t tho, people still get addicted to both of these more milder forms of cocaine and heroine. My just not at the same risk level.
And the risk declined drastically if taken at therapeutic levels (like following prescription drug directions).
Another thing you have to consider is genetics in brain receptors.
Some people’s brain responds strongly in eurphoria to a drug while someone else’s does not.
For example. Opiates. I personally do not get euphoria from opiates. I instead get a bad headache and extreme nausea. I had an injection of morphine about a year ago for a ER visit. Not only did it not help the pain at all, I had unpleasant effects from the drug. I was not high. But I was woozy. It was incredibly awful.
I actually told them not to give me optiates because I already knew I didn’t tolerate them but that’s what I get for going to a 1 star ER.
So how is it possible that a drug like an opiate wouldn’t make me high or at the very least block the pain I was having ?
Genetics. My mother is the same. The part of other peoples brain that the opiate drugs bind to, will not accept the drug in my brain. Instead the drug is binding to some other receptors. Starting a cascade of signals that give me delirium, nausea, and a headache.
They are different enough to make a drug have a completely different effect in two animals of the same species.
It’s things like that, that make designing drug therapies incredibly difficult.
So even when we try to give a basis run down of what drugs are highest risk, we can’t say that’s true for everyone.
There is zero chance I could become addicted to opiate based drugs. They literally are aversive to me.
It also means if I get injured and I’m in severe pain, there isn’t much that can be done (so pretty big trade off. Here’s hoping I don’t get a painful terminal cancer).
So at present. Schedule 1 drugs have a specific definition. And that definition indicates a high risk of dependency.
You can read up more about how a drug qualifies for schedule 1. And schedule 2. I think that will help you understand the system better.
biggerbogboy@sh.itjust.works 2 weeks ago
Sounds like a meth-cocaine orgasm is optimal then!
tomiant@piefed.social 2 weeks ago
Meth and coke? Good luck with that ejaculation
Matticus@lemmy.world 2 weeks ago
Doctors hate this one simple trick
gigastasio@sh.itjust.works 2 weeks ago
The arrow on the y axis implies that there something beyond meth that does even better… 🤔
Agent641@lemmy.world 2 weeks ago
The feeling you get when you peel the protective film off the door of a brand new refrigerator
crank0271@lemmy.world 2 weeks ago
And then replace it with a black garbage bag because it’s a Samsung fridge
cyrano@piefed.social 2 weeks ago
The dragon 🐉 is at the end. That’s why you chase it
tomiant@piefed.social 2 weeks ago
DMT springs to mind.
Rai@lemmy.dbzer0.com 2 weeks ago
Having done all of these, DMT does not have the same kind of dopamine release. It is, however, the far most interesting of all of these. But definitely not something I’m ready to casually do at a party, unlike a couple bumps of fine Peruvian nasal fuel.
bestboyfriendintheworld@sh.itjust.works 2 weeks ago
Pyrovalerones like MDPV and alpha-PVP are even stronger and more euphoric stimulants than meth. McAffee loved that stuff.
scytale@piefed.zip 2 weeks ago
Heroin? I’ve read about people describing it as even better than an orgasm.
Cevilia@lemmy.blahaj.zone 2 weeks ago
So you’re telling me that four orgasms is roughly equivalent to doing cocaine?
Hold that thought.
JasonDJ@lemmy.zip 2 weeks ago
Have I been getting really bad coke?
Rai@lemmy.dbzer0.com 2 weeks ago
Having had oodles of bad to mediocre coke in my days and then having 90+% pure (tested myself) I honestly think this graph is misleading, and coke is waaaaay higher.
The problem is, meth dumps your serotonin and feels good by itself, while coke requires you to be doing something that dumps your sweet brain chems to really feel good-good. I don’t know the science behind it but it’s been explained to me. Doing coke and sitting around watching a show is meh. Doing blow and playing a stimulating video game or doing a project that feels good or talking your partner’s ear off (and they yours in return) about ridiculous shit feels incredible.
But yeah. If you need to do a couple lines of coke to really feel it, it’s not good. If you’re getting zooted off a couple bumps, that’s the good stuff.
starman2112@sh.itjust.works 2 weeks ago
girlfriend called… DECLINE! busy whore!
busy with my METH
tomiant@piefed.social 2 weeks ago
Crystal meth cured my autism
naught@sh.itjust.works 2 weeks ago
i take a handful of tylenol with my meth to maintain autistic homeostasis
tomiant@piefed.social 2 weeks ago
autistic homeostasis
🤣
Tkpro@lemmy.world 2 weeks ago
Source since op didn’t provide it
Timestamp: 14:35
lemmydividebyzero@reddthat.com 2 weeks ago
You knew the video or can we already reverse image search the frame of a video?
QuinnyCoded@sh.itjust.works 2 weeks ago
not the person you’re asking, but I was about to comment the source also and I saw the video earlier
bitwolf@sh.itjust.works 2 weeks ago
Of Person is 80%, what’s 100%?
BananaTrifleViolin@lemmy.world 2 weeks ago
Probably 80% increase from baseline. 0% is that background existential dread we all feel.
humorlessrepost@lemmy.world 2 weeks ago
Right guys? Right?
SCmSTR@lemmy.blahaj.zone 2 weeks ago
Orgasm plus cuddles
Asetru@feddit.org 2 weeks ago
So an orgasm will reduce the dopamine level to only 80% of where it’s supposed to be? Like you come and immediately just feel a little weird and disappointed?
Like, I get it. It’s just nice to see it in writing.
LodeMike@lemmy.today 2 weeks ago
No. 80% increase.
yermaw@sh.itjust.works 2 weeks ago
Its that moment when you sober up and see what’s on your screen. Cant alt+f4 fast enough.
InvalidName2@lemmy.zip 2 weeks ago
Doing crystal meth will lift you up until you break.
ImgurRefugee114@reddthat.com 2 weeks ago
Percentage of what?
TurboToad@lemmy.world 2 weeks ago
Dopamine release
dabaldeagul@feddit.nl 2 weeks ago
Your baseline dopamine levels. So 80% more = 1.8x your normal dopamine.
Twakyr@feddit.org 2 weeks ago
How meth destroys Europe? Was that the title?
tias@discuss.tchncs.de 2 weeks ago
The trick is to time the cocaine and crystal meth ingestion so that they peak at the same time that you orgasm, leading to an 80% * 300% * 1400% = 7460% dopamine increase.
Kyrgizion@lemmy.world 2 weeks ago
Your permanently burned out synapses will thank you for the vacation.
tomiant@piefed.social 2 weeks ago
They weren’t doing much for me anyway
adhocfungus@midwest.social 2 weeks ago
I heard the dev didn’t intend for those to stack and it’s nerfed in the next patch.
arrow74@lemmy.zip 2 weeks ago
I heard there’s a flaw in the code meaning they cannot patch the old consumables and have to release a new version instead.
It’s unclear if the pre-patch consumables will be usable after the patch or if they’ll simply be deleted.
Imo the best move is to collect and sell to the hoarders. Not worth the risk of losing all that time I’d rather be able to buy the new stuff even if it doesn’t stack
lime@feddit.nu 2 weeks ago
if you cum, snort, and puff at the same time, your body goes into recovery mode
sp3ctr4l@lemmy.dbzer0.com 2 weeks ago
… What?
No.
You just have to hold a nose boop for 10 seconds, release, then three quick headpats.
naeap@sopuli.xyz 2 weeks ago
Nah, after snuffing it takes a few minutes
You can actually pretty easily time this
The only thing is: puffed will acted more or less immediately. So you’ll need to be able to smoke while jacking off, which can lead to serious injuries, when you’re already intoxicated
So, wouldn’t recommend to synchronize it that much ;-)
icelimit@lemmy.ml 2 weeks ago
And a maintenance hatch opens, allowing access to all the gloppy bits.
taiyang@lemmy.world 2 weeks ago
Careful, some of us on older hardware have a bug where we overflow and crash the system. My second cousin bricked his system just by stacking the last two.
YoSoySnekBoi@kbin.earth 2 weeks ago
I've been running calculations for the last 10 minutes trying to figure out where tf you got 7460% from lmao
ryedaft@sh.itjust.works 2 weeks ago
Yeah, I’m getting 10700%
tias@discuss.tchncs.de 2 weeks ago
Yeah I made a mistake. The proper calculation for an increase by 80%, then 300%, then 1400% should be
x*(1+0.80)(1+3.00)(1+14.00) =
x1.84*15 = 108 = 10800%
Thedogdrinkscoffee@lemmy.ca 2 weeks ago
How does gain this power?