Drug mimics exercise in mice, raises metabolism, increases endurance, burns fat

Comments

• PoorlyWrittenPapyrus@lemmy.world ⁨1⁩ ⁨year⁩ ago

  This is incredible news is you are a mouse.

  Let’s hope it translates to humans without also causing cancer or some other horrible condition as all of these miracle drugs seem to.

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  • DocBlaze@lemmy.world ⁨1⁩ ⁨year⁩ ago

    also scary for humans - a super race of gigantic, muscular rats with high libidos (that multiply very quickly) and want to overtake our food supply

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    • toasteecup@lemmy.world ⁨1⁩ ⁨year⁩ ago

      If they can solve global warming, I’m fine being a pet. Just gimme my videogames and I’ll tend to some crops.

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    • DLSchichtl@lemmy.world ⁨1⁩ ⁨year⁩ ago

      I can think of one group that would be totally okay with this…

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    • vaultdweller013@sh.itjust.works ⁨1⁩ ⁨year⁩ ago

      Look ive seen a documentary and the best way to deal with cracked up Vermin is 19 hellstorm rocket batteries, also a wizard with a gold fetish helps.

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• Erasmus@lemmy.world ⁨1⁩ ⁨year⁩ ago

  Soon to be available for humans for the low low price of 10k per dose. Thanks to big Pharma.

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  • jeffw@lemmy.world ⁨1⁩ ⁨year⁩ ago

    MUH R&D COSTS!!!1

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  • FaceDeer@kbin.social ⁨1⁩ ⁨year⁩ ago

    And then a few years later in generic form for much, much less.

    I'm actually not terribly put out by the initial high cost of these things, especially when it's something that isn't a vital life-saving treatment that people have no choice but to try. Every new technology starts out expensive and gets cheaper as competition arises and better manufacturing techniques are developed.

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• Supermariofan67@programming.dev ⁨1⁩ ⁨year⁩ ago

  So meth?

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  • jackoneill@lemmy.world ⁨1⁩ ⁨year⁩ ago

    yeah i’m with you this sounds like they gave mice some meth and went heeyyyyyyy weight loss

    no shit

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  • sagrotan@lemmy.world ⁨1⁩ ⁨year⁩ ago

    Heroin. In the right amount it actually stops aging a bit. Emphasis on THE RIGHT AMOUNT. It stops other things too, though.

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• Brkdncr@artemis.camp ⁨1⁩ ⁨year⁩ ago

  Why is science trying to make gym-bro mice?

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  • RobotToaster@mander.xyz ⁨1⁩ ⁨year⁩ ago

    Image

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• Crozekiel@lemmy.zip ⁨1⁩ ⁨year⁩ ago

  Okay but what does it do with the energy from burning the fat?? Like, if you aren’t moving or doing anything you just have an excess of energy going where?

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  • RobotToaster@mander.xyz ⁨1⁩ ⁨year⁩ ago

    In summary, the ERR agonist SLU-PP-332 functions as an exercise mimetic inducing an acute aerobic exercise program that leads to myriad physiological adaptations that are associated with exercise including increased skeletal muscle oxidative fibers, increased fatty acid oxidation, and enhanced exercise endurance

    Gainz

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  • SuiXi3D@kbin.social ⁨1⁩ ⁨year⁩ ago

    Well, waste energy is expelled as heat so… I bet they heat up. Kinda like how if you take a stimulant that raises your heart rate but you aren’t doing anything at the same time, you tend to feel warmer.

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    • mosiacmango@lemm.ee ⁨1⁩ ⁨year⁩ ago

      You exhale fat.

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    • lucidinferno@lemmy.world ⁨1⁩ ⁨year⁩ ago

      So, Extremis from Iron Man 3?

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• Imgonnatrythis@sh.itjust.works ⁨1⁩ ⁨year⁩ ago

  So cocaine?

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  • jscummy@sh.itjust.works ⁨1⁩ ⁨year⁩ ago

    If you’ve ever done cocaine it absolutely wrecks your cardio/endurance in the long term

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    • Imgonnatrythis@sh.itjust.works ⁨1⁩ ⁨year⁩ ago

      Who said anything about long term?

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    • Tigbitties@kbin.social ⁨1⁩ ⁨year⁩ ago

      And you're a fucking lasy ass the next day and the only really chears you up is either more or shitty food.

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  • DocBlaze@lemmy.world ⁨1⁩ ⁨year⁩ ago

    The most natural diet supplement of all time (unfortunately it tasted terrible until they combined it with banana cream smoothie powder).

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• FlyingSquid@lemmy.world ⁨1⁩ ⁨year⁩ ago

  “In mice.”

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• Heavybell@lemmy.world ⁨1⁩ ⁨year⁩ ago

  Yes, give it to me.

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• MNByChoice@midwest.social ⁨1⁩ ⁨year⁩ ago

  helping mice run nearly 50% further than they could before, all without the mice lifting a paw.

  I am surprised. I felt certain there would be a muscle orientation issue. Glad they are figuring this out.

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• ForestOrca@kbin.social ⁨1⁩ ⁨year⁩ ago

  Papers Referenced in the above article:
  A Synthetic ERR Agonist Alleviates Metabolic Syndrome
  https://pubmed.ncbi.nlm.nih.gov/37739806/

  Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity
  https://pubs.acs.org/doi/10.1021/acschembio.2c00720?ref=pdf

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• RobotToaster@mander.xyz ⁨1⁩ ⁨year⁩ ago

  Where can I buy several kilos? asking for a friend.

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  • DocBlaze@lemmy.world ⁨1⁩ ⁨year⁩ ago

    I also had that same idea of creating a small army of super swole mice to help me pull off the ultimate heist on the federal reserve, but since you thought of first I guess you can have it

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• tvbusy@lemmy.dbzer0.com ⁨1⁩ ⁨year⁩ ago

  Like someone on lemmy once said: tools like this will make the climate situation worse since people can eat what they want and not have to worry about gaining weight. The drug is certainly going to help a specific group of patients but it’s very likely that it’ll be abused.

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  • Kushan@lemmy.world ⁨1⁩ ⁨year⁩ ago

    But also will be of huge benefit to disabled folks and potentially helps solve a major issue with long term space travel

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• guythatsits@lemmy.world ⁨1⁩ ⁨year⁩ ago

  I’ll be interested when it also mimicks the psychological effects of working out.

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• Valmond@lemmy.mindoki.com ⁨1⁩ ⁨year⁩ ago

  Creates addiction… ?

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  • DocBlaze@lemmy.world ⁨1⁩ ⁨year⁩ ago

    SAY HELLO TO MY LITTLE FRIEND!

    (the rats are my friends)

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