Is this the first human trial, or just the first officially sanctioned one?
IIRC there was that one guy who experimented on himself and cured his lactose intolerance.
... found it: https://www.youtube.com/watch?v=J3FcbFqSoQY
Nearly 8 years ago.
First-In-Human Trial Of CRISPR Gene-Editing Therapy Safely Lowered Cholesterol, Triglycerides
Submitted 3 weeks ago by AfterNova@lemmy.world [bot] to technology@lemmy.world
https://finance.yahoo.com/news/first-human-trial-crispr-gene-145600945.html
Comments
palordrolap@fedia.io 3 weeks ago
offspec@lemmy.world 3 weeks ago
I feel obligated to mention that he doesn’t modify his own genes, he infects himself with a modified bacteria that produces lactase.
TonyTonyChopper@mander.xyz 3 weeks ago
you can just eat yogurt to get the same results
ClockworkOtter@lemmy.world 3 weeks ago
First-in-human just means it’s the first time that specific therapy is being tested on humans instead of animals (e.g. mice, dogs, monkeys), and the primary objective of the trial is to test that it’s safe for use in humans. It doesn’t refer to the concept of gene editing or lowering cholesterol.
pound_heap@lemmy.dbzer0.com 3 weeks ago
was safe and reduced LDL cholesterol by nearly 50% and reduced triglycerides by about 55%
From the referenced article
Cort@lemmy.world 3 weeks ago
Thought emporium?
Yep thought emporium.
But I think the Chinese scientist that experimented on babies did it few years before that even.
billwashere@lemmy.world 3 weeks ago
We lowered your cholesterol. But you now have horns and crave the taste of human flesh.
nicolauz@feddit.org 3 weeks ago
I don’t understand why you used “but”, where it should clearly be “as well as”…
Nioxic@lemmy.dbzer0.com 3 weeks ago
Why would you lower cholesterol?
The body literally makes it because you need it. People with high cholesterol live longer…
pmc.ncbi.nlm.nih.gov/articles/PMC11901585/
Youd wanna lower arterial plaque so cholesterol doesnt get stuck?
An arterial calcium scan is the best indicator for heart disease etc.
Not cholesterol.
TranscendentalEmpire@lemmy.today 3 weeks ago
The body literally makes it because you need it
For what?
People with high cholesterol live longer…
I don’t think that’s really a conclusive study. It only focuses on people who are already 80 or older and ignores the majority of people who suffer from cardiovascular issues that don’t make it to their eighties because of it.
From this study you could also conclude that people who have a natural resistance to high cholesterol live longer.
Youd wanna lower arterial plaque so cholesterol doesnt get stuck?
Plaque forms when cholesterol lodges to the walls of arteries. This happens at a greater rate when you have more lower density cholesterol in your blood.
An arterial calcium scan is the best indicator for heart disease etc. Not cholesterol
But calcium buildups are formed from clacified plaque, which is made from cholesterol…
If all forms of high cholesterol were really beneficial Americans would modern day Methuselahs.
surewhynotlem@lemmy.world 3 weeks ago
for what?
You might not need cholesterol. But that’s what brains are made out of.
wreckedcarzz@lemmy.world 3 weeks ago
I have high cholesterol. I can send you some if you want. Promise it will make you live longer, it says so on this lemmy comment…
HeyThisIsntTheYMCA@lemmy.world 3 weeks ago
Is it butter or olive oil? I want to taste good when I die
mholiv@lemmy.world 3 weeks ago
You need to reach out to the scientists to let them know! You could save lives with your insight!
Beacon@fedia.io 3 weeks ago
No dude, you're WAAAAAAY overstating what that paper says.
termaxima@slrpnk.net 3 weeks ago
I’m sorry to inform you that you have fallen for online propaganda. Cholesterol definitely is bad for you.
melfie@lemy.lol 3 weeks ago
Our results challenge the common view that longevity is invariably associated with low cholesterol levels.
While single study like this is far from conclusive, it wouldn’t surprise me to learn that a diet of mostly minimally processed plant oils and animal fats would result in better longevity than the typical Western diet comprised mostly of the “hateful 8”.
bitjunkie@lemmy.world 3 weeks ago
Nerds will do anything not to go for a jog
LapGoat@pawb.social 3 weeks ago
to be fair, jogging is kinda the worst.
mmmac@lemmy.zip 3 weeks ago
Nerd
bluefootedbooby@sopuli.xyz 3 weeks ago
Anything not to eat less butter, huh?
HeyThisIsntTheYMCA@lemmy.world 3 weeks ago
With what “side” effects?
Beacon@fedia.io 3 weeks ago
Bring it on!!!
Autoimmune disease? GONE!
Acne? GONE!
Don't like your eye color? CHANGE IT!
Exeous@lemmy.world 3 weeks ago
For rich by rich, only rich get.
MolochHorridus@lemmy.ml 3 weeks ago
Now, sing with me: “Only in America…”
FerretyFever0@fedia.io 3 weeks ago
Shit's going to get pretty weird imo. Hopefully it isn't used for eugenics purposes (it probably will be, let's be honest). I don't think that people should be able to change so many things that they become unrecognizable, but I can understand changing a few things per person, voluntarily, obviously.
Beacon@fedia.io 3 weeks ago
I believe in bodily autonomy. People should be able to do whatever they want to their own body.
black_flag@lemmy.dbzer0.com 3 weeks ago
There are a lot more problems in trying to create the infrastructure to enforce sanctioned uses of any readily accessible technology than there is in the use of said tool. The people who want to do the most harm inevitability wind up in the oversight position, while society tends to create enforcement mechanisms at a social, interpersonal level organically already.
jerkface@lemmy.ca 3 weeks ago
Don’t want to stop being cruel and violent? Want to keep committing atrocity against vulnerable individuals while destroying human-supporting environments on Earth, for absolutely no practical benefit to yourself? Well good news! Investor-driven medical research is here to protect you (and only you) from the consequences of your monstrous choices!
Beacon@fedia.io 3 weeks ago
What are you talking about?
termaxima@slrpnk.net 3 weeks ago
And enjoy the 5 cancers you just caused yourself by editing other genes that happen to contain the targeted sequence !