Comment on For when joints give you a sore throat and edibles give you a tummy ache

Formfiller@lemmy.world ⁨21⁩ ⁨hours⁩ ago

• bitchkat@lemmy.world ⁨8⁩ ⁨hours⁩ ago

  It’s a lot? Who knew.

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• REDACTED@infosec.pub ⁨18⁩ ⁨hours⁩ ago

  Is it? I have no clue about what counts as high but I did try out 125mg gummy bear once as a seasoned smoker and it was 8/10. The high wasn’t extreme, it was more focused on “body high” while also lasting 2x as long.

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  • EmpathicVagrant@lemmy.world ⁨10⁩ ⁨hours⁩ ago

    The bioavailability of a suppository instead of edible is insane by comparison. Someone who gets a lower reaction from a ~100mg edible would get similar effects from a suppository less than half that strength because it’s being absorbed by another part of the body - different receptors stimulated and less for it to travel through.

    TLDR; if your edible tolerance is high your stomach lining is just more resistant

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    • captainlezbian@lemmy.world ⁨10⁩ ⁨hours⁩ ago

      Also most people who only consume casually are fucking wrecked by 100mg edibles. When I’m not being drug tested I take like one 10 mg edible once or twice a month and am hit hard by it. Something in the 20-50 range is normally tolerated by folks who use more than me and have higher tolerance. The only people I know who can do 100 are stoned regularly, often to deal with chronic pain

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      • PacMan@sh.itjust.works ⁨10⁩ ⁨minutes⁩ ago

        I know people that can rip 300 -500 mg and it’s no problem. If I take 30 I’m absolutely wrecked and having the best nights sleep every

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      • Siethron@lemmy.world ⁨10⁩ ⁨hours⁩ ago

        I rarely get high. Last time was 5mgs gummy and it SENT me, like I forgot how to move for a couple of hours. Back when I was in college and a borderline stoner I probably wouldn’t have even have noticed that dosage. Tolerance is a hell of a drug.

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      • EmpathicVagrant@lemmy.world ⁨9⁩ ⁨hours⁩ ago

        This comment is correct dotcom

        I’m that last group, used to need a 100mg two capsule to make it through the day. I’m down to 2 25s a day instead but some of the mental pain still seeps through.

        My dose is ~60-80 depending on symptoms but I’m trying to break it into smaller parts to fine tune the effects

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    • Corkyskog@sh.itjust.works ⁨10⁩ ⁨hours⁩ ago

      I thought edible tolerance mostly had to do with a genetic marker that dictates how much of an enzyme those peoples liver produced.

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      • EmpathicVagrant@lemmy.world ⁨9⁩ ⁨hours⁩ ago

        Sometimes genetic, sometimes you can shift it with the type (sublingual oil absorbs in the gums, bypasses the liver process which it into 11-Hydroxy thc)

        The suppository would do this too, just with a different membrane and easier to have higher doses.

        Anecdotals below •I had one patient who ate a lot of liver after he had to quit drinking, and his edible tolerance dropped •My edible tolerance dropped when I lost ~100lbs •a colleague quit all other substances and tolerance dropped there too

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  • Formfiller@lemmy.world ⁨14⁩ ⁨hours⁩ ago

    I just know gummy’s around here come in 5 or 10 mg so 100 would be way too much

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    • some_kind_of_guy@lemmy.world ⁨11⁩ ⁨hours⁩ ago

      Some people have trouble absorbing them. I have the opposite problem. Half of a standard 5mg gummy is more than enough!

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• undeffeined@lemmy.ml ⁨20⁩ ⁨hours⁩ ago

  Depends hevaily on tolerance levels, no? Or would the fast absortion in the intestine make the high more potent?

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