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HollowNaught@lemmy.world ⁨4⁩ ⁨weeks⁩ ago

I’m currently writing a small literature review on tgf-b and SMAD signalling in cancer for uni rn

And I’m really confused why this one paper’s talking about how miR-520h induces the tgf-b/smad7 pathway but also binds to and suppresses smad7

Like why on earth is it activating the tgf-b/smad7 pathway, a pathway that stops stuff like the epithelial mesenchynal transition, if it’s just going to bind to smad7 anyway???

Worst thing is, I can’t find any other papers on why this actually happens

I swear I’m just dumb at times ;-;

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prex@aussie.zone ⁨4⁩ ⁨weeks⁩ ago
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- tetris11@lemmy.ml ⁨4⁩ ⁨weeks⁩ ago
  I’ll take two scoops
  
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BluesF@lemmy.world ⁨4⁩ ⁨weeks⁩ ago
Ah, yes. Of course. I understand your frustration entirely because of my deep understanding of the specific situation.

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fossilesque@mander.xyz ⁨4⁩ ⁨weeks⁩ ago
Would a list of tools and search engines be helpful?

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- HollowNaught@lemmy.world ⁨4⁩ ⁨weeks⁩ ago
  That would be very helpful 🥴
  
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  - fossilesque@mander.xyz ⁨2⁩ ⁨weeks⁩ ago
    Sorry, better late than never. Will dm you. Others are welcome too.
    
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runner_g@lemmy.blahaj.zone ⁨4⁩ ⁨weeks⁩ ago
Cell signalling pathways was the worst part of microbial genetics for me. Luckily I don’t have to deal with that anymore as my day to day is digital PCR and NGS.

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