kadup
@kadup@lemmy.world
- Comment on I totally missed the point when PeerTube got so good 3 hours ago:
We used to post pictures of beans on Lemmy and get five hundred replies
- Comment on Feds in Catalonia, Spain think everyone using a Google Pixel must be a drug dealer 1 day ago:
Police are not the brightest in any society.
It’s a literal job requirement. If you’re smart, you’re not going to blindly follow orders. Police cognitive testing literally discards candidates that perform well in intellectual tasks. This is not a conspiracy or a joke, it’s how police works.
- Comment on Are we still doing moths? Here is a happy one to start your day. 3 days ago:
You’d be surprised at how quickly you can become partially incapacitated due to dehydration in certain scenarios.
Go out to a nice summer break in a sunny Brazilian beach, and if you’re not careful with purposely drinking water, even when you don’t feel like you need it, you might soon find yourself being carried by an emergency worker or friend.
- Comment on Pretty woman stepping on you 4 days ago:
Ah, I see we have a cultured scholar among us
- Comment on Financially rewarding and you will always have a job 4 days ago:
The difference is not my point at all.
If my brother, at a very young age, had made the reasonable decision of pursuing higher education as a path in life, and due to a wide variety of circumstances is in financial trouble and I could help…
Guess what, I’m helping. I do not give a fuck if there’s a difference, my guy. And I also know my brother would stop in the middle of a career defining work meeting and come rescue me if I was in trouble.
And I wouldn’t trade that kind of relationship for your world view.
- Comment on Financially rewarding and you will always have a job 4 days ago:
If that’s how you see our familiar relations sure, you’re your own individual. But boy wouldn’t I want to be your family member.
- Comment on Bitch shape attack 1 week ago:
That’s a fantastic question… which is exactly what I’m pursuing in my master’s degree right now :). The goal will be to have a full metabolic map showing all the involved genes and how they interact, when they’re triggered (and by which signaling pathways) and how it all comes together for placental development.
- Comment on Bitch shape attack 1 week ago:
Basically, yes. Viruses came up with the syncitins to fuse with host cells, then when they infected us and integrated their genome we had the code for making these proteins… and turns out “invading tissue” was a really useful tool for the embryo.
- Comment on Bitch shape attack 1 week ago:
Happily! Basically, the true placenta we mammals (Eutheria) have is what allows such a long gestation period. Unlike our closely related marsupials, that quickly deplete their resources and must give birth, our placenta allows for a continuous exchange of nutrients. This involves a quite complicated process of embryonic tissue invading the uterine wall, so you can imagine the kind of immunological regulation that must be taking place for that to work.
So you’d assume we have several genes highly specific to our placenta that appear when we Eutherians first appeared… right? No! Turns out the vast majority already existed in jawed vertebrates (our common ancestor with sharks), then quite a lot show up in bony fish (our common ancestor with most things you call fish), and just one shows up in Tetrapoda (our common ancestor with amphibians).
So most of the framework for developing an organ such as the placenta already existed for millions of years, so what exactly was missing before it can finally show up in evolutionary history? The two genes that are absolutely required for this whole crazy “let’s invade the mother’s uterine wall tissue but NOT trigger her immune system” part: CSF2 and a group of closely related genes called syncitins.
Syncitins are the star here, because they’re actually a gene that came from ancient retroviruses. In the virus, they were expressed in the envelope and controlled the fusion between the viral particle and the host cell. These viruses got integrated into our genome, and this “fusion with the host cell” mechanism became extremely useful and crucial for the placenta, basically allowing it to exist.
- Comment on Yep, I actually own 7,255 games on Steam. I’ve played 23% of my library. I regret nothing. 1 week ago:
It works in the same way that dumping your GameCube games and running them on Dolphin works… It’s quick and easy, but it’s against the ToS and requires breaking DRM.
Steam’s DRM is weak, and in some interviews some Valve developers even gave hints that this is on purpose. Many Steam games will simply run without Steam if you just double click the .exe in the install folder, and the vast majority that only rely on Steam’s DRM can be opened by running a free “Steam Emulator” software that pretends to be an active Steam account with a correct license.
- Comment on How would I repurpose a work laptop? 1 week ago:
Works fine on Proton, it even creates the mod folder in the correct place
- Comment on Yep, I actually own 7,255 games on Steam. I’ve played 23% of my library. I regret nothing. 1 week ago:
While you’re not wrong, by that logic, it’s actually fairly trivial to take my Steam downloads drive and run it on any computer even without my Steam account.
- Comment on Bitch shape attack 1 week ago:
Mammals wouldn’t have a chorioallantoic placenta at all if not for a virus integrated into our genome. Mapping when in evolution the genes responsible for placental development was my first participation in scientific research, so I love this topic.
- Comment on 413524 Gang, rise up! 1 week ago:
I don’t conform to societal norms.
- Comment on xkcd #3109: Dehumidifier 2 weeks ago:
Some 90’s microwaves actually used some chips to measure humidity and using a little reference table adjust how long certain foods need to cook for, for instance, popcorn can be popped perfectly without burning and almost without leftover kernels if you can measure how much water is being released. The same goes for cooking frozen meats, vegetables, and so on.
But what we get in modern ones instead are horrendous touchscreens, simple timers that never quite match the food they promise to work on, and Wi-Fi.
- Comment on 'Technofascist military fantasy': Spotify faces boycott calls over CEO’s investment in AI military startup 2 weeks ago:
I can’t really stand behind and defend boycotting every defense tech investor.
I can. Easily.
- Comment on Facebook is asking to use Meta AI on photos in your camera roll you haven’t yet shared 2 weeks ago:
And don’t let their Like buttons and cookies exist in other websites too
- Comment on Apple just proved AI "reasoning" models like Claude, DeepSeek-R1, and o3-mini don't actually reason at all. 5 weeks ago:
That entire paragraph is much better at supporting the precise opposite argument. Computers can beat Kasparov at chess, but they’re clearly not thinking when making a move - even if we use the most open biological definitions for thinking.
- Comment on Apple just proved AI "reasoning" models like Claude, DeepSeek-R1, and o3-mini don't actually reason at all. 5 weeks ago:
Apple is significantly behind and arrived late to the whole AI hype, so of course it’s in their absolute best interest to keep showing how LLMs aren’t special or amazingly revolutionary.
They’re not wrong, but the motivation is also pretty clear.
- Comment on Google Restricts Android Sideloading—What It Means for User Autonomy and the Future of Mobile Freedom – Purism 5 weeks ago:
Certainly depends on where you live.
Unlocking a Samsung phone is trivial here.
- Comment on iFixit says the Switch 2 is even harder to repair than the original 5 weeks ago:
not generations before If by “Generations” you mean the literal previous generation that was advertised as backwards compatible and where many of the games won’t receive specific patches precisely because running natively and better was one of the key features of the new console… Sure, I guess.
- Comment on iFixit says the Switch 2 is even harder to repair than the original 5 weeks ago:
with consoles, it’s 100% of the time
Several Switch 1 games are facing issues on Switch 2, including broken textures, crashes and weird behavior. This whole “consoles are 100%!” idea has been dead since the Xbox 360 and PlayStation 3 generation.
- Comment on What's going on with Borderlands 2? Steam is giving it for free, but the game has 23% positive recent reviews. 5 weeks ago:
Making up scenarios and claiming to know what the response would be sure is a way to make an argument.
I mean, the worse most laughable way, but it’s a way indeed.
- Comment on What's going on with Borderlands 2? Steam is giving it for free, but the game has 23% positive recent reviews. 5 weeks ago:
So should Walmart stop selling products that fit my personal preferences too? Say goodbye to animal fats, products made in the US, ultra processed foods, some fruit I just don’t like the taste of, all Nestlé products…
I think you get the point.
- Comment on What's going on with Borderlands 2? Steam is giving it for free, but the game has 23% positive recent reviews. 5 weeks ago:
What’s Steam got to do with Borderlands 2 having a rootkit?
- Comment on How does AI-based search engines know legit sources from BS ones ? 1 month ago:
LLMs can’t describe themselves or their internal layers. You can’t ask ChatGPT to describe it’s censorship.
Instead, you’re getting a reply based on how other sources in the training set described how LLMs work, plus the tone appropriate to your chat.
- Comment on If AI was going to advance exponentially I'd of expected it to take off by now. 1 month ago:
To be fair, smart background removal was a feature from Picasa over a decade ago. We just didn’t call everything “AI” to make shareholders happy.
- Comment on OpenAI featured chatbot is pushing extreme surgeries to “subhuman” men 1 month ago:
The promise was that people would literally stop going to real life music shows to watch them on Second Life, buying fake cans of sponsored Coca-Cola and inviting friends to one night stands on their digital flats.
The reality is that we forgot about the game in less than two years and the surviving community is small, even if they pay a lot.
That’s exactly what’s going to happen to AI agents promising to replace an entire department or the creative team in a studio.
- Comment on Console war, console war never changes 1 month ago:
Unfortunately, while Valve outsourcing repairs and parts to iFixit is great for most regions, iFixit stopped shipping to my country a few years ago, so this complicates things quite a lot :(
- Comment on Console war, console war never changes 1 month ago:
We can’t criticise a massive price increase on games and insane markups for a 480p webcam in 2025 because… People are having fun?
I mean, I can have lots of fun with asbestos too.