Comment on Xenon

Deconceptualist@lemm.ee ⁨1⁩ ⁨year⁩ ago

• drosophila@lemmy.blahaj.zone ⁨1⁩ ⁨year⁩ ago

  Don’t listen to the people who say it works by displacing oxygen. It would never be used as a general anesthetic if that was the mechanism of action.

  Xenon has been used as a general anesthetic, but it is more expensive than conventional anesthetics.

  Xenon is a high-affinity glycine-site NMDA receptor antagonist.[155] However, xenon is different from certain other NMDA receptor antagonists in that it is not neurotoxic and it inhibits the neurotoxicity of ketamine and nitrous oxide (N2O), while actually producing neuroprotective effects.[156][157] Unlike ketamine and nitrous oxide, xenon does not stimulate a dopamine efflux in the nucleus accumbens.[158]

  Xenon has a minimum alveolar concentration (MAC) of 72% at age 40, making it 44% more potent than N2O as an anesthetic.[164] Thus, it can be used with oxygen in concentrations that have a lower risk of hypoxia.

  en.wikipedia.org/wiki/Xenon

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  • Deconceptualist@lemm.ee ⁨1⁩ ⁨year⁩ ago

    I didn’t think to check Wikipedia for pharmacology info haha. Thanks.

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• FooBarrington@lemmy.world ⁨1⁩ ⁨year⁩ ago

  Yeah. If you spray it on a hammer and hit someone’s head with it, it knocks them right out.

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• Shou@lemmy.world ⁨1⁩ ⁨year⁩ ago

  It works by dispersing oxygen from the blood. The lack of oxygen gives you a high. Which is can turn deadly if you don’t unhook when passing out.

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  • Deconceptualist@lemm.ee ⁨1⁩ ⁨year⁩ ago

    Isn’t that the same as Nitrogen, like Tar_alcaran@sh.itjust.works said? That doesn’t sound like there’s any unique mechanism to Xenon.

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    • Shou@lemmy.world ⁨1⁩ ⁨year⁩ ago

      Correct

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• ZILtoid1991@lemmy.world ⁨1⁩ ⁨year⁩ ago

  oh, so it’s a “medicine drug”…

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• Cort@lemmy.world ⁨1⁩ ⁨year⁩ ago

  iirc it’s a dissociative.

  I remember Hamilton’s pharmacopeia doing an episode on it. Apparently it is/was popular in Russia.

  Here’s a video of Hamilton doing some: youtu.be/dj25HO48Gxw

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  • anomnom@sh.itjust.works ⁨1⁩ ⁨year⁩ ago

    Is it me or is he just slightly asphyxiated after the first breath?

    We messed with sulfur hexaflouride a while back, and it’s kinda difficult to exhale it all without putting your head between your knees and breathing hard.

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• threelonmusketeers@sh.itjust.works ⁨1⁩ ⁨year⁩ ago

  Is there more to the story?

  Not that I’m aware of. I’m assuming Tom was referring to its anaesthetic effects, which I don’t think have been widely studied.

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• Tar_alcaran@sh.itjust.works ⁨1⁩ ⁨year⁩ ago

  At the worst, you can use it like people use nitrogen. To get a very brief high from lack of oxygen (and then possibly die)

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