fullsquare

@fullsquare@awful.systems

• ⁨Comment⁩ on ⁨Why are so many after-shave lotion perfumed ?⁩ ⁨⁨1⁩ ⁨day⁩ ago⁩:

  Tax reasons perhaps? In some countries ethanol with (certain kinds of) perfume mix can be taxed as denatured alcohol, otherwise some other kind of denaturant would be needed

• ⁨Comment⁩ on ⁨Did you know you could get premium capcut without paying?⁩ ⁨⁨3⁩ ⁨days⁩ ago⁩:

  yeah piracy community is three blocks down, fuck off

• ⁨Comment⁩ on ⁨same shit every day, on god⁩ ⁨⁨3⁩ ⁨days⁩ ago⁩:

  for ccgt it’s more like 2/3 for gas turbine, 1/3 for steam turbine split, even more uneven for diesel/steam because diesel exhaust is much colder

• ⁨Comment⁩ on ⁨same shit every day, on god⁩ ⁨⁨3⁩ ⁨days⁩ ago⁩:

  and fuel cells

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨5⁩ ⁨days⁩ ago⁩:

  as a citizen of a country whose government (-owned company) makes insulin, this reads weird to me

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨6⁩ ⁨days⁩ ago⁩:

  good. generic biosimilars cost like 1/5 of the on-patent thing price

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨6⁩ ⁨days⁩ ago⁩:

  fyi this fella has no training in chemistry or medicine and is just some random ass programmer with severe case of “saving the world from my homelab” symdrome

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨6⁩ ⁨days⁩ ago⁩:

  I don’t think it’s a thing because even the same insulin analogue from different manufacturer can have different dosing

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  90% of drug candidates fail in clinical trials

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  couple of reddit threads suggest that this is something you can do, but you have to be evasive around american border guard later if you go in person

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  i mean i don’t think about it as a separate budget line because if you don’t have that you get police raids and investigation instead of normal business, but yea. insulin is purified using HPLC, so at all times you get some of analytical data about fractions you just made, so some of QC, not all, but already something, already happens at this point

  my point is that actual manufacturing costs will be low because biotech scalability logic is that you need to make yeast or something that makes peptide you like and then all you need to do is keep bioreactor alive and happy. lots of what is left is in purification

  also it’s an injectable so it’s gonna be kept to some standards that non-injected drugs aren’t

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  there are multiple short-acting and long-acting insulins because you can’t patent other people’s things, but now it’s all off-patent. just take your stainless steel bioreactor and preparative HPLC, cook up a batch, wait ten years for biosimilar approval and you’re good to go

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  I know not every state can or are willing to do this

  this kind of thing scales well, i see no reason why after california has it set up, other states couldn’t get insulin from them, or chip in

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  it might just be in glass vial and freezing broke it

• ⁨Comment⁩ on ⁨Insulin⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  also european, but with some background: the problem is that there is natural (as in, unmodified) generic insulin available, it’s just that it sucks compared to everything else. you see, insulin is a peptide that is supposed to appear, do some signalling, then disappear and unmodified insulin copies this thing exactly. the problem is, most of the time, you don’t want to do that, you’d like insulin to last longer than usual, which means changes to it that make breakdown slower, or adding something that makes it stick to albumin, which has similar effect because it hides insulin somewhere enzymes can’t reach it. this means less frequent dosing and less changes in insulin activity over time. there are also other insulins that start acting faster than natural, and this is also due to a couple of modifications in its structure

  for another example, ozempic was not the first drug in its class, it’s also a modified peptide, and it can be injected s.c. once a week, compared to previous iteration (liraglutide) that requires daily injections. if natural peptide is injected i.m. instead, its halflife is half an hour, and in serum it’s only two minutes (it gets released a bit slower than it is metabolized)

• ⁨Comment⁩ on ⁨Do you think there would eventually be technology to delete/replace memories (like the *Men In Black* device). How much do you fear such technology? (like misuse by governments/criminals)⁩ ⁨⁨2⁩ ⁨weeks⁩ ago⁩:

  yes you can do it and it’s so easy it sometimes happens accidentally en.wikipedia.org/wiki/False_memory

• ⁨Comment⁩ on ⁨Refrigerator ads are finally here!⁩ ⁨⁨2⁩ ⁨weeks⁩ ago⁩:

  There’s a slight chance that we’ll see a

  Sent from my fridge using Tapatalk

  in the future

• ⁨Comment⁩ on ⁨Refrigerator ads are finally here!⁩ ⁨⁨2⁩ ⁨weeks⁩ ago⁩:

  For now

• ⁨Comment⁩ on ⁨Refrigerator ads are finally here!⁩ ⁨⁨2⁩ ⁨weeks⁩ ago⁩:

  achoo

• ⁨Comment⁩ on ⁨Utter nonsense⁩ ⁨⁨5⁩ ⁨weeks⁩ ago⁩:

  i don’t mean beta-oxidation, it’s just a series of separated normal reactions. i mean something like this: when first learning about ketones, you might learn about aldol condensation, which has enol as a nucleophile and another carbonyl as electrophile. at some other point you might learn about strecker reaction, which has iminium ion as electrophile and cyanide as nucleophile. but really, what you can do is mix and match, and you can pair enolizable ketone and iminium (mannich reaction) or carbonyl and cyanide (cyanohydrin formation) and then generalize, for example you don’t need strictly ketone for mannich, you can use any electron rich conjugated system like malonate or nitroalkane anion (henry reaction) or phenol or indole. to figure this out you need to study mechanisms. these last two are usually treated as variants of friedel-crafts reaction, but really categories like this are fake

  and to get that right, you need to know how these reactive intermediates look like, how reactive they are, what influences their stability which means that ochem starts with discussion of carbocations, carboanions, radicals, their shapes and orbitals involved, hyperconjugation, solvent effects and the like. and then first reactions taught are sn1/sn2, because these showcase these fundamentals nicely, and from there, it’s about introduction of more compound classes

  we only had synthons introduced during lecture at around 4th year, and only for ochem path, it’s not doing a lot at that point and imo would have much more impact right after ochem intro course

• ⁨Comment⁩ on ⁨Utter nonsense⁩ ⁨⁨5⁩ ⁨weeks⁩ ago⁩:

  i always thought that the idea of synthons should be taught early on en.wikipedia.org/wiki/Synthon

• ⁨Comment⁩ on ⁨Utter nonsense⁩ ⁨⁨5⁩ ⁨weeks⁩ ago⁩:

  i’d say it’s more important to learn mechanisms because this way you can notice these patterns of reactivity easier. at some point you’d only get new reactions that are really just pieces of other reactions you know put in a new way

• ⁨Comment⁩ on ⁨Utter nonsense⁩ ⁨⁨5⁩ ⁨weeks⁩ ago⁩:

  there’s zero reason to make chart like this, it’s both barely comprehensible and touching surface level stuff only (where are palladium couplings for one)

• ⁨Comment⁩ on ⁨Mom they're fighting again⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  Image

• ⁨Comment⁩ on ⁨Physics!⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  These things are under high voltage, so no. And then there’s several kg of mercury inside

• ⁨Comment⁩ on ⁨Physics!⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  no, but they will also kill you (but not by magic)

• ⁨Comment⁩ on ⁨The AI that we'll have after AI (Doctorow)⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  the same way they did in 2021

• ⁨Comment⁩ on ⁨AI might be creating a ‘permanent underclass’ but it’s the makers of the tech bubble who are replaceable | Van Badham⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  ah yes chatbot seller says these things will become so capable, they’re gonna destroy the world, just you wait and see, but need trillion dollars in financing first. op have you already eaten your daily recommended pebble today?

• ⁨Comment⁩ on ⁨Have you ever been shown the "clarity"?⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  if your brain does that without drugs i’d suggest you check it with a neurologist because it’s not usual. maybe there will be some new kind of epilepsy named after you

• ⁨Comment⁩ on ⁨Have you ever been shown the "clarity"?⁩ ⁨⁨1⁩ ⁨month⁩ ago⁩:

  I have excellent vision normally and don’t need glasses, I can see things from extremely fair away and my eyes have a wide FOV (my peripheral is great)

  Image

  it sounds a lot like psychedelics and not any usual human experience