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Comment on For when joints give you a sore throat and edibles give you a tummy ache

EmpathicVagrant@lemmy.world ⁨7⁩ ⁨hours⁩ ago

The bioavailability of a suppository instead of edible is insane by comparison. Someone who gets a lower reaction from a ~100mg edible would get similar effects from a suppository less than half that strength because it’s being absorbed by another part of the body - different receptors stimulated and less for it to travel through.

TLDR; if your edible tolerance is high your stomach lining is just more resistant

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captainlezbian@lemmy.world ⁨6⁩ ⁨hours⁩ ago
Also most people who only consume casually are fucking wrecked by 100mg edibles. When I’m not being drug tested I take like one 10 mg edible once or twice a month and am hit hard by it. Something in the 20-50 range is normally tolerated by folks who use more than me and have higher tolerance. The only people I know who can do 100 are stoned regularly, often to deal with chronic pain

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- Siethron@lemmy.world ⁨6⁩ ⁨hours⁩ ago
  I rarely get high. Last time was 5mgs gummy and it SENT me, like I forgot how to move for a couple of hours. Back when I was in college and a borderline stoner I probably wouldn’t have even have noticed that dosage. Tolerance is a hell of a drug.
  
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- EmpathicVagrant@lemmy.world ⁨5⁩ ⁨hours⁩ ago
  This comment is correct dotcom
  
  I’m that last group, used to need a 100mg two capsule to make it through the day. I’m down to 2 25s a day instead but some of the mental pain still seeps through.
  
  My dose is ~60-80 depending on symptoms but I’m trying to break it into smaller parts to fine tune the effects
  
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Corkyskog@sh.itjust.works ⁨7⁩ ⁨hours⁩ ago
I thought edible tolerance mostly had to do with a genetic marker that dictates how much of an enzyme those peoples liver produced.

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- EmpathicVagrant@lemmy.world ⁨5⁩ ⁨hours⁩ ago
  Sometimes genetic, sometimes you can shift it with the type (sublingual oil absorbs in the gums, bypasses the liver process which it into 11-Hydroxy thc)
  
  The suppository would do this too, just with a different membrane and easier to have higher doses.
  
  Anecdotals below •I had one patient who ate a lot of liver after he had to quit drinking, and his edible tolerance dropped •My edible tolerance dropped when I lost ~100lbs •a colleague quit all other substances and tolerance dropped there too
  
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