Most drugs/medicines are taken in higher doses because the body filters or neutralizes the compounds so much that only a small portion gets into the blood.
That’s still different.
Even if the total quantity of the drug is small in the system once it gets there, it’s not the same as how LSD works. The drug, likely because of its similarity to serotonin and size , is readily absorbed into the blood stream and passes the blood brain barrier easily. It is not filtered out to a small percentage of it’s original dose like most drugs/medicines.
You surely are aware of this ?
There are very few drugs that can work in small dosages like LSD. As I said, fentanyl is one.
I’m not sure what you are talking about with dox trips.
Drugs like DMT /Ayahuasca also can’t be ingested unless they are mixed with a maoi inhibitor.
Most psychedelic research chemicals (nbome) are much different than lsd with different pharm and effect properties.
It’s possible that LSD is released more quickly on the tongue than nbome drugs. So as soon as it hits the tounge the drug is delivered. I don’t think there is research on this. But I’ll look into it.
But this idea that it’s not neutralized in the stomach is false. There is plenty of research on that.
Rai@lemmy.dbzer0.com 18 hours ago
I took DOC back in the 00s (on purpose) and it was an extremely wild 20-some hours. Second weirdest thing I’ve done (the weirdest is Foxy by a WIDE margin,) but I still had a relatively good time due to having a great and comfortable set and setting. By hour ten, I was VERY ready to be done.
JoeBigelow@lemmy.ca 18 hours ago
I was too poor to care, been on plenty of non acid trips on chems that lasted wayyy too long. Some were really fun, some were abject terror. Never got to try foxy sadly. MXE was the strangest chem I’ve tried and holey hell, I turned into an interdimentional worm crawling through the multiverse. It was super overwhelming.
Rai@lemmy.dbzer0.com 14 hours ago
I never tried MXE! I wanted to as I have enjoyed ket in the past, but the times I was offered MXE, I just eas not in the right headspace/environment.
Foxy is fucking insane. It had the normal visual and auditory hallucinations, but it’s the only thing I’ve ever tried that gave me full on temporal distortions. My partner-at-the-time and I were listening to familiar music. The music would get lower in pitch and streeeetch out, each individual note playing for longer and longer, until the tone went back to normal and the notes stopped being played for so long. When it was low and slow, our bodies got soooo heavy, we would just lay on the floor. When the notes got fast and higher pitched, our bodies would be light with energy. VERY weird stuff.
JoeBigelow@lemmy.ca 14 hours ago
MXE and ket are really different. The hole threshold and the visual nature are way stronger ime