Only because I had to explain the differences recently and it’s top of mind:

Satisfactory - Main goal is efficient usage of limited amount of throughput. Resource nodes are static, and efficiency is the name of the game. My favorites usually end up a spaghetti mess of belts, everything being fed the correct amount of inputs and all outputs being accounted for.

Factorio - Main goal is THE FACTORY MUST GROW. Your factory need more input to run 100%? You could figure out how to optimize everything that comes before it, orrrr just slam more out. Resources are randomly generated, and while you can exhaust deposits, there’s always more on the horizon. Explore. Expand. Exterminate. ENLARGE FACTORY. Usually ends up in a beautiful mess of a factory with bots zipping around, and the power flickers every now and then when the biters think they are more powerful that explosives/concentrated beams of light.