niucllos
@niucllos@lemm.ee
- Comment on ... 3 weeks ago:
Sure, there will be examples of problems in any field that has hundreds of thousands to millions of humans working in it. That doesn’t mean there’s a broad crisis, and it doesn’t mean that most research is faked or fallible. In your 2004 example, all of the data wasn’t faked, some images for publication were doctored. There’s been potential links between alzheimer’s and aBeta amyloids since at least 1991 (1), long before this paper that posited a specific aB variant as a causal target. Additionally, other Alzheimer’s causes and treatments are also under investigation, including gut microbiome studies since at leasg 2017 (2). Finally, drugs targeting aB proteins to remove brain plaques work in preclinical trials, indicating that the 2004 paper was at least on the right track even if they cheated to get their paper published. This showcases science working well: bad-faith actors behaved unethically, but the core parts of their work were replicated and found to be effective, so some groups followed that to clinical trials which are still ongoing, and others followed other leads for a more holistic understanding of the disease.
Also, I’d very much argue that human neurological diseases are both bleeding edge and niche, which inherently means that recognizing problems in studies will take more time than something that is cheaper or faster to test and validate, but problems will eventually be recognized as this one was.
- Cras P, Kawai M, Lowery D, Gonzalez-DeWhitt P, Greenberg B, Perry G. Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci USA. 1991;88:7552–6.
- Cattaneo, A. et al. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol. Aging 49, 60–68 (2017).
- Comment on ... 4 weeks ago:
I wouldn’t call it a broad crisis, and it isn’t universal. More theoretical sciences or social sciences are more prone to it because the experiments are more expensive and you can’t really control the environment the way you can with e.g. mice or specific chemicals. But most biology, chemistry, etc that isn’t bleeding edge or incredibly niche will be validated dozens to hundreds of times as people build on the work and true retractions are rare
- Comment on [deleted] 4 weeks ago:
A pride flag pin is not political swag but also correlates very strongly to voting blue, and far-right nutjobs could run with that
- Comment on [deleted] 4 months ago:
I think it applies equally, the fallen victims will be held up and honored no matter what they had done, the shooter will be an evil antifa devil no matter who he was, and Trump will be the barely escaped Messiah no matter if this was a lone wolf attempt or a conspiracy
- Comment on Tesla’s Share of U.S. Electric Car Market Falls Below 50% 4 months ago:
I don’t buy it, tbh. I’ve been hearing some variant of “Tesla isn’t growing more and the stock is overvalued” or in the last five years “Musk is an idiot and is going to tank the stock” since I started paying attention to the markets circa 2012. Musk is a fascist piece of shit, but he does have some quality–and it may just be having more money than God and thus having a sort of wealth inertia–that keeps the stock merrily tripping its way upwards. I bought three shares several years ago on a whim, and between the upward growth and the stock splits I’ve sold my initial investment amount 3x already and could sell it three more times today and still have Tesla stock leftover
- Comment on Tesla’s Share of U.S. Electric Car Market Falls Below 50% 4 months ago:
The other factor not yet mentioned is charging time/range. There are EVs with more range, and EVs with faster charging times, and EVs that are cheaper, but there are no EVs with a comparable long-range driving ability as the Tesla for less money. The Hyundai ioniq 6 is comparable now but it’s new, untested, and doesn’t really have a used market
- Comment on Tesla is recalling its Cybertruck for the fourth time to fix problems with trim pieces that can come loose and front windshield wipers that can fail | The new recalls each affect over 11,000 trucks 4 months ago:
For many of those years it was the only electric pickup truck. And also, yes people do like the Tesla name. Musk and growing competition has done a ton to tank the reputation lately, but until just a couple years ago Tesla was seen as far and away the best and most advanced electric car, and sometimes car period, by tons of people. That perception shifts slowly outside of well-informed groups, and the Musk hate is really only affecting well-informed left wing groups
- Comment on Fisker reaches end of the road and files for bankruptcy 5 months ago:
All these dumb companies chasing the wrong high margin class imo. Tesla did it right, start with the sports car: the EV powertrain plays well to its strengths, their big advantageous use case isn’t 600 mile road trips, and they don’t need to tow. Starting with the mom-mobiles and dad’s pavement princess puts you on the worst footing by needing obnoxiously large amounts of the most expensive component, needing to meet road trip or towing standards, and catering to a market that by definition has other big spending priorities, e.g. their kids or whatever they want to tow. If Ford’s first electric mustang had been a cobra equivalent rather than a sportier electric escape I suspect they would have had a much better time.
- Comment on Car dealers say they can’t sell EVs, tell Biden to slow their rollout 11 months ago:
You should be able to, but US non-car infrastructure is so abysmal that there’s a strong chance you can’t safely unfortunately
- Comment on Samsung is planning a 400-500$ foldable for 2024 1 year ago:
And help one of the 5 benefits they listed?
- Comment on After luring customers with low prices, Amazon stuffs Fire TVs with ads 1 year ago:
They don’t make it obvious at all, in fact they do their best to seem like you can’t
- Comment on Scientific progress is declining due to bureaucratization of research. Scientific innovations should make ‘zero to one’ breakthroughs, instead making ‘one to many’ improvements to existing innovations 1 year ago:
US funding for basic research–the type that will lead to the truly paradigm-shifting breakthroughs–has also been in decline for 50+ years as a proportion of GDP. While bureacracy could be an obstacle, the much larger one is insufficient resources to fund a lot of moonshots that may fizzle or may result in 'zero to one’s innovation, as the author states
- Comment on YouTube TV, which costs $73 a month, agrees to end “$600 less than cable” ads 1 year ago:
I have an aeropress and have only ever used a metal filter with it! I’ve had normal paper filtered aeropress coffee and I can’t taste the difference