dgdft
@dgdft@lemmy.world
- Comment on [Episode] JUJUTSU KAISEN Season 3: The Culling Game Part 1 • Jujutsu Kaisen: Shimetsu Kaiyuu - Zenpen - Episode 8 discussion 15 hours ago:
I’m truly in love with this season. What an absolute masterpiece of an episode.
One of the strengths of this show is making characters that stick in your head after only one episode, and that introduction of Higuruma is a perfect case study.
- Comment on 29 years since our homecoming queen was taken from us 2 days ago:
Everything else I post on this site is just cover for my Nico shilling, tbh.
- Comment on 29 years since our homecoming queen was taken from us 3 days ago:
Weird crossover, but for the Twin Peaks fans who like EDM, Nicolas Jaar’s breakout DJ set samples this interview as its opener:
- Comment on [deleted] 4 days ago:
What you’re describing is a teratoma, not a vestigial twin.
- Comment on The "western hemisphere" rubs me the wrong way 4 days ago:
The prime meridian roughly separates the two major clusters of land mass on the planet, which have undergone wildly different patterns of human settlement and development.
The line itself is arbitrary, but the concept of the hemispheres as shorthand geopolitical labels for these clusters is very much not arbitrary.
- Comment on Bacteria Frozen in Ancient Underground Ice Cave Found to be Resistant Against 10 Modern Antibiotics 4 days ago:
Even if we ignore any ethical concerns, when you’re sampling from an extreme environment, the strains you’re finding will, with >99.9% certainty, have substantially diverged from a biologically identical ancestor that’s spent a fair number of generations infecting hosts.
So you also get a weird Ship-of-Theseus type question of “are these still really the same bacteria?”. And if you assume they are going to be different strains after adapting to different environments, then you can also safely assume that whatever strain you’re sampling in an extreme environment has a >99.9% probability of being in the potentially-harmful, contextually-harmful, or non-harmful bucket, by virtue of the fact you found it isolated in the wild rather than in living hosts.
To put it a little more simply: if you’re looking for something with a demonstrated ability to infect people, you’ll probably find that inside or nearby people, not in an icy, remote cave.
- Comment on Bacteria Frozen in Ancient Underground Ice Cave Found to be Resistant Against 10 Modern Antibiotics 4 days ago:
How are you distinguishing those ideas?
Are we talking about “has actually been found infecting human patients”?
- Comment on Bacteria Frozen in Ancient Underground Ice Cave Found to be Resistant Against 10 Modern Antibiotics 4 days ago:
It does to the target audience.
What you’re missing is that Linnaean taxonomy breaks down when discussing bacteria, and the line between strain/species doesn’t really exist.
Bacteria swap a lot of genetic material asexually, including across dramatically different species. Pathogenicity can also be dramatically modulated by presence of other species and environmental conditions.
The idea of a particular strain or species of bacteria being inherently pathogenic is a weird and surprisingly flimsy one.
- Comment on Bacteria Frozen in Ancient Underground Ice Cave Found to be Resistant Against 10 Modern Antibiotics 5 days ago:
It did.
Psychrobacter SC65A.3 is a strain of the genus Psychrobacter, which are bacteria adapted to cold environments. Some species can cause infections in humans or animals.
If it’s not immediately obvious: The intended takeaway is that this particular strain probably isn’t pathogenic itself, but it’s completely plausible that such resistance can spread via HGT to pathogenic species, within the genus or not.
- Comment on Microsoft 365's buggy Copilot 'Chat' has been summarizing confidential emails for a month — yet another AI privacy nightmare 6 days ago:
This part applies to all customers:
v. Use of Your Content. As part of providing the AI services, Microsoft will process and store your inputs to the service as well as output from the service, for purposes of monitoring for and preventing abusive or harmful uses or outputs of the service.
And while Microsoft has many variations of licensing terms for different jurisdictions and market segments, what they generally promise to opted-out enterprise customers is that they won’t use their inputs to train “public foundation models”. They’re still retaining those inputs, and they reserve the right to use them for training proprietary or specialized models, like safety-filters or summarizers meant to act as part of their broader AI platform, which could leak down the line.
That’s also assuming Microsoft are competent, good-faith actors — which they definitely aren’t.
- Comment on This MF is quadrupling down and dropping Alien files before dropping the full, unredacted Epstein Files. GODDAMN. 1 week ago:
All common English-language standards and style guides will tell you the article should be based on the pronunciation of the acronym.
- Comment on Microsoft 365's buggy Copilot 'Chat' has been summarizing confidential emails for a month — yet another AI privacy nightmare 1 week ago:
This is some pathetic chuddery you’re spewing…
You wouldn’t assume that QA can read every email you send through their mail servers ”just because”
I absolutely would, and Microsoft explicitly maintains the right to do that in their standard T&C, both for emails and for any data passed through their AI products.
www.microsoft.com/en-us/servicesagreement#14s_AIS…
v. Use of Your Content. As part of providing the AI services, Microsoft will process and store your inputs to the service as well as output from the service, for purposes of monitoring for and preventing abusive or harmful uses or outputs of the service.
- Comment on Microsoft 365's buggy Copilot 'Chat' has been summarizing confidential emails for a month — yet another AI privacy nightmare 1 week ago:
Microsoft is almost certainly recording these summarization requests for QA and future training runs; that’s where the leakage would happen.
- Comment on He made beer that’s also a vaccine. Now controversy is brewing 1 week ago:
Then he should definitely know better and know why what he’s doing will ruin any chance he has of rapid certification.
Asking naively: In what way would this self-experiment have bearing on later trials done by other parties?
Setting aside the dangers of self-experimentation, there’s a host of issues ranging from the individual psychological (doctors are as vulnerable to sunk-cost fallacy as anyone) to broader problems of replication issues (publishing one-off successes/failures can lead to misinformation regarding the viability of a given therapy).
IMO the main issue I saw in this case was administering to family members, to put my cards on the table, but I think given the risk profile, it was acceptable in context if they were well-informed and had an epipen handy.
All research involves risk, and a key pillar of bioethics is the requirement of informed consent. Generally speaking, no one is better informed than a principal investigator to give that consent, and no one has better-aligned incentives to ensure safety.
I also think any doing serious biomed research is well-educated enough to understand standards of evidence and treat small-N case studies for what they are.
Ginseng, Garlic, St. John’s Wort, and Acai Berries underwent the same fad promotions.
This is going too far in my book; wishful thinking is the problem here, not self-experimentation in a clinical context. I agree these supplements are overhyped, but do you really think we should be barring people from trying out garlic and reporting what they experience?
The ethical issue in the case of grifter supplements is trying to financially profit from a contrived narrative, not the inherent process of trying things on a small scale and reporting those findings.
- Comment on He made beer that’s also a vaccine. Now controversy is brewing 1 week ago:
But self-experimentation is a huge taboo in bio-ethics for a litany of reasons. If this guy was a proper professional, he’d know that.
He’s a professional virologist with the NIH.
Speaking from my own professional lens, I think the consensus around self-experimentation in biomed is way less black and white you’re making it out to be. What are your particular scruples in this case, if you don’t mind me asking?
- Comment on 2 weeks ago:
That’s my question too: Why ignore the focus of the peer-reviewed research to latch onto a political talking point about how this isn’t significant because it impacts so few people?
- Comment on 2 weeks ago:
You’re talking about the incidence rate as a way of downplaying the importance of the research, when the research is interesting specifically because they were able to identify such a highly specific mechanism that only happens in such rare circumstances.
The incidence rate isn’t a focus of the article, so why else is that what you’re lasering at if not to make a statement?
- Comment on 2 weeks ago:
This paper is immunology research, not a political message. You don’t need to drag this in here.
- Comment on 2 weeks ago:
I understand why people are downvoting, but identifying and explaining these misfires in somatic hypermutation is actually really novel and interesting work.
Somatic hypermutation and its role in common autoimmune diseases is something I desperately wish would make its way into popular knowledge. I think the name makes people think the concept is way more difficult than it really is.
- Comment on Why I Don’t Believe in a Lost Advanced Civilization...Yet 3 weeks ago:
It’s the opposite: Most people are likely downvoting because Hancock-esque arguments aren’t worth addressing.
This is remedial choir-preaching.
- Comment on Exposed Moltbook Database Let Anyone Take Control of Any AI Agent on the Site 3 weeks ago:
It’s just a meme site that was posted to HN and took off.
No investors or purpose beyond putting a pool of chatbots together and watching the slop proliferate.
- Comment on Piefed admin settings that allow to enable or disable content filters (they are disabled by default, see body for details) 3 weeks ago:
unless you consider it hard coded because its coded into the codebase
That’s precisely the common definition and understanding of the term.
- Comment on Adderall vape? 1 month ago:
Sounds like you don’t want the public knowing about the Shadow People who are constantly watching us, huh?
- Comment on The Lioness does not... 1 month ago:
The lioness’ joke was kinda butchered by the typos though.
- Comment on Dan Carlin’s Mania for Subjugation III Released (Alexander the Great series) 2 months ago:
Not my place to tell you what kinda soup you like.
¯\_(ツ)_/¯
He spent decades as a talk radio host, and records in a professional sound studio. I get how the vocal range can be offputting, but it’s a deliberate artistic choice.
That being said, I have run his releases through a compressor (i.e. a software program that normalizes the volume level) in the past for car listening to good effect. YMMV, but might be worth a shot if that’s your main hangup.
- Comment on Dan Carlin’s Mania for Subjugation III Released (Alexander the Great series) 2 months ago:
For the unfamiliar, Dan Carlin is the biggest history podcaster bar-none. His work tends to be extremely long-form, with this episode clocking in at 4:15 and taking 11 months of development time.
Happy early Xmas, folks!
- Dan Carlin’s Mania for Subjugation III Released (Alexander the Great series)dancarlin.substack.com ↗Submitted 2 months ago to history@lemmy.world | 4 comments
- Comment on The Mysterious Forces Steering Views on Hacker News 2 months ago:
Lobste.rs might be up your alley.
- Comment on The Mysterious Forces Steering Views on Hacker News 2 months ago:
Did I miss something? They didn’t post any real evidence at all unless there was a link I didn’t find.
What the post is describing sounds exactly like the post getting flagged by users, then uncensored by the mod team later on.
I’m both an HN user of more than a decade, AND a massive HN hater. I’m predisposed to assume the worst, but there’s very little meat to this allegation.
- Comment on The Mysterious Forces Steering Views on Hacker News 2 months ago:
To spare anyone else the click, this is about one blogger malding that his flamebait posts got flagged.
First post cited was about leaving Element/Matrix because they’re bad, second was an Omarchy showcase.
