New study shows Alzheimer’s disease can be reversed to achieve full neurological recovery—not just prevented or slowed—in animal models

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• solrize@lemmy.ml ⁨4⁩ ⁨days⁩ ago

  IN MICE

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  • MalReynolds@slrpnk.net ⁨4⁩ ⁨days⁩ ago

    Which don’t get Alzheimer’s. Mice lie, monkeys exaggerate.

    That said, this study is cause for cautious optimism. The mechanism they’ve targeted cleared symptoms in 'two of these mouse models: One carried multiple human mutations in amyloid processing; the other carried a human mutation in the tau protein. ’ Mosreso, it does it by modulating NAD+, long a target of interest in AD. From the paper

    Nicotinamide adenine dinucleotide (NAD+) homeostasis is central to cellular resilience against oxidative stress, DNA damage, neuroinflammation, blood-brain barrier (BBB) deterioration, impaired hippocampal neurogenesis, synaptic plasticity deficits, and neurodegeneration.

    As such it is not only of interest to sufferers of AD but the aging population in general.

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• YetAnotherNerd@sopuli.xyz ⁨4⁩ ⁨days⁩ ago

  Anybody got an account on whatever fedia.io is?

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  • ragica@lemmy.ml ⁨4⁩ ⁨days⁩ ago

    Don’t know what fedia is, but based on the graphic and title the story is the same as this I saw last month…

    case.edu/…/new-study-shows-alzheimers-disease-can…

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    • YetAnotherNerd@sopuli.xyz ⁨4⁩ ⁨days⁩ ago

      Kind of what I was figuring, but wasn’t sure if it had different info. Thanks!

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  • Davel23@fedia.io ⁨4⁩ ⁨days⁩ ago

    Right here.

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    • YetAnotherNerd@sopuli.xyz ⁨4⁩ ⁨days⁩ ago

      Okay… mind sharing whatever is linked in there? Is it just the earlier story?

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