Red loctite on fastners that small has a recipe for being a bad time if it sets up proprly, I find some of the small screws around the hotend can already be prone to stripping due to things like plastic buildup thats hard to remove.

At least on the dragon, theres a sizeable gap between the inner and outer portions of the heatbreak and some distance between the block and the heatbreak, I’d be surprised if the threads get hot enough to worry about even without the hotend fan.