It depends. Using OPs scenario, if all data, ads and updates, are served from data.samsung.com, then the pi hole can’t help. But if ads are served from ads.samsung.com and updates from updates.samsung.com, then you can blacklist the ads while still receiving the updates.

My experience with a Vizio is that the pi is blocking a lot of the “phoning home” connections, but the ads seem to be integrated with the software that allows me to use apps, so I still see them when I use the TV’s apps. More and more though, I’m using the HDMI port with my HTPC.