For anyone wondering, FMT = Fecal Microbiota Transplants.
It’s exactly what it sounds like; through oral or rectal.
MaximilianKohler@lemmy.world 10 months ago
Some relevant info I shared yesterday:
Resistance can be solved by restoring lost microbes with FMT: humanmicrobiome.info/antibiotics/
gonta@mander.xyz 10 months ago
Nurse_Robot@lemmy.world 10 months ago
I imagine burping after taking it through the oral route would be a special kind of horrible
godzillabacter@lemmy.world 10 months ago
That’s not exactly true. FMT isn’t going to fix your MRSA colonization, and it doesn’t inherently remove resistance genes from the population of bacteria in your gut. If those genes produce a survival disadvantage, they may be selected against and become a minor serotype in your GI tract, but that doesn’t mean that it is eradicated.
Also, you seem to be sharing a lot of links from humanmicrobiome.info, which I would advise against. While I can appreciate the primary author’s dedication to the topic and willingness to cite his sources, his website is not peer reviewed, and he explicitly states he is a proponent of FMT, introducing bias which is not being balanced by a peer review process. Not to mention he admits he is a layperson with no formal medical training/experience. I would direct you to IDSociety.org which is the home of the Infectious Disease Society of America, who publishes the actual guidelines used by infectious disease physicians in North America.
MaximilianKohler@lemmy.world 10 months ago
MRSA is actually covered in the cited links. Here’s one for example academic.oup.com/ofid/article/6/7/ofz288/5522275.
The gut microbiome regulates the entire body, including the immune system and other body site’s microbiomes humanmicrobiome.info/systemic. You can see what a great resource it is – very handy to provide categorized citations.
Anyone is welcome to contribute and peer review it.
godzillabacter@lemmy.world 10 months ago
Yes, it covers intestinal colonization with MRSA. Unfortunately Staph aureus is an uncommon GI pathogen, and the majority of detrimental infections secondary to MRSA come from skin-flora translocation to produce surgical site infections/blood stream infections, as well as translocation from the nares into the lungs to produce pneumonia. We thankfully have another method of nares decolonization. While metallobetalactamase producing Pseudomonas is mentioned as well, I have a very low suspicion that FMT would be useful for resistant Pseudomonal pneumonia or diabetic foot infections/osteomyelitis. FMT certainly has a role to play in ID, particularly for enteric gram negatives and VRE within the alimentary canal, but is not a cure-all for antimicrobial resistance.