godzillabacter

@godzillabacter@lemmy.world

• ⁨Comment⁩ on ⁨In the era of remakes and remasters, what niche game would you like to see receive the treatment?⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  The Sly Cooper Trilogy +/- Thieves in Time

• ⁨Comment⁩ on ⁨Would a surgical puncture to the skull relieve a pressure headache?⁩ ⁨⁨5⁩ ⁨months⁩ ago⁩:

  No idea unfortunately, but definitely not to release pressure. You don’t get air in your brain, it’s all fluid. Outside of the hospital, all the drains drain to somewhere internal, usually the abdominal cavity

• ⁨Comment⁩ on ⁨Would a surgical puncture to the skull relieve a pressure headache?⁩ ⁨⁨5⁩ ⁨months⁩ ago⁩:

  Am doctor. Outside of very rare and specific causes of headache, no this wouldn’t fix anything, just put you at risk for infections.

• ⁨Comment⁩ on ⁨Would a surgical puncture to the skull relieve a pressure headache?⁩ ⁨⁨5⁩ ⁨months⁩ ago⁩:

  Am a doctor, this wasn’t actually a migraine and is not how migraines happen. Shunts are placed for elevated intracranial pressure, which can occur for a number of reasons, and do cause headaches. But it’s a very uncommon cause of headaches and a shunt will not fix your actual migraines or tension headaches.

• ⁨Comment⁩ on ⁨Would it be possible to run Pi-hole, Octoprint and Home Assistant on the same RPi 3 mod. B?⁩ ⁨⁨10⁩ ⁨months⁩ ago⁩:

  Not OP but loss of the Pi results in loss of network connectivity. A headache if you’re home and never doing anything time-critical on the network. A disaster if you or anyone else is dependent on the network for anything time-sensitive (virtual doctors appointment, work call, etc), or you’re away from home and unable to directly VPN to your router to reconfigure DNS settings.

• ⁨Comment⁩ on ⁨Why do we use average instead of mode?⁩ ⁨⁨11⁩ ⁨months⁩ ago⁩:

  It’s not that we don’t use mode, there are definitely times mode is used. It’s just that mean (and median as well) contain a lot more useful information about distributions that we often care about. For a normal distribution mean, median, and mode should all be identical. So why do we use mean? Because mathematically, the mean is what underpins the formula for the normal distribution, not median or mode, and when you’re talking about doing math with normal distributions mean is the thing to talk about (along with standard deviation).

  We use median a lot too, you probably just don’t hear it called median very often. The median is useful in non-normal distributions, and it defines the 50th percentile, so along with the 25%-ile and 75%-ile you’ve got your quartile distributions. We use these all the time to talk about grades in schools, or when we talk about home prices distributions in a given area, or salaries within a given field.

  We use mode too, again just by a different name most of the time. Any time you’ve asked “what’s the most common blank” you’re basically asking for a mode. When we talk about “average” income in a country, we’re usually actually talking about median or mode. Favorite animal? Answered as a mode.

  You have to use the right statistical tool for your question: unfortunately English doesn’t do a good job of conveying this without math jargon.

• ⁨Comment⁩ on ⁨Tech Employee Who Went Viral for Filming Her Firing Has No Regrets⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  Can’t tell if we’re agreeing or disagreeing. Companies should totally be able to hire on short-term contracts. But it should be clear that it is a temporary contract from the start, not a bait-and-switch from long-term employment to hire-and-fire.

• ⁨Comment⁩ on ⁨Tech Employee Who Went Viral for Filming Her Firing Has No Regrets⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  I mean if the only way they’re gonna have jobs is through predatory hiring practices that could leave them fired and without severance, then yeah. Because if the company is planning on hiring these younger workers for the long-haul, then this shouldn’t be a significant change. I think overall national policy should discourage unnecessary high-turnover and predatory hiring. I’m sure there will be situations this is still unavoidable, but that doesn’t mean we have to endorse it by way of law/policy.

• ⁨Comment⁩ on ⁨Tech Employee Who Went Viral for Filming Her Firing Has No Regrets⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  I’m going to digress from the economics a tad and focus on the ethics of this. I feel like companies should be on the hook for this. You should invest in capital (including human labor) based on your confidence in its expected return. Companies should not be able to hire a myriad of workers for funzies and not have to meaningfully consider if that person will be necessary in 6 months. If it is a legitimate business venture, then the cost of potential severance for new hires should be folded into the economics of the decision to pursue that venture. Larger severance pay/worker protections encourage employers to not utilize exploitative hiring practices.

• ⁨Comment⁩ on ⁨A tiny radioactive battery could keep your future phone running for 50 years⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  It depends on the half life of the element in question. The most comparable concrete thing we can compare this to with real numbers because we know it works is an RTG. RTGs are solid-state generators, but people could colloquially refer to them as “batteries” and not be terribly wrong. They take a quantity of a radioactive material and allow it to decay, using the heat given off to establish a thermal gradient which is then converted to electricity via thermocouples. Most of these are “fueled” with Pu-238 (at least the ones for spacecraft), which has a half life of 87.7 years. That means in 87.7 years, if you started with 4kg of Pu when you built it, you’d have only 2kg of Plutonium left. If the Pu decayed only into stable isotopes (it doesn’t) then your radioactive emissions/decay would also be exactly halved at this time. If the electrical system is perfectly efficient this would also halve the electrical power produced.

  I provide this all as background because to answer your question you have to know three key factors about the device to determine the lifetime of the battery. The half-life of the isotope used, the minimum electrical requirements of the device you’re powering, and the amount of radioactive material in the initial battery. The battery’s lifetime is determined by when decay will decrease the ongoing energy output below the minimum current and voltage requirements needed by the battery. The longer the half life of the isotope, the slower this decrease is and the less initial overpowering that is required.

  Ex. If you use an isotope with a 12.5 year half life for a “50-year” battery, you would need to start with 8 times the material needed for your minimum power output requirements. If you use an isotope with a 200 year half life, you only need 19% more starting mass than you minimum requirement. The first battery will produce 8x the power at the very beginning, while the second will only produce 18% more.

• ⁨Comment⁩ on ⁨NYPD faces backlash as it prepares to encrypt radio communications | New York | The Guardian⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  I know, which is why my example was about providing the patient’s name over the radio.

• ⁨Comment⁩ on ⁨NYPD faces backlash as it prepares to encrypt radio communications | New York | The Guardian⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  EMS communication over unencrypted channels is limited by HIPAA, patient information must be kept vague to protect patient privacy. In the event that, say, an individuals name needs to be given to the receiving facility to facilitate review of records prior to arrival by the ER physician, some other method of communication has to be used.

• ⁨Comment⁩ on ⁨Yesit is!⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  You make physics come alive!

• ⁨Comment⁩ on ⁨AppleTV complete replacement opinions⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  All remote based typing is awful, T9 included. I can’t speak for everyone, but I can type with swipe gestures on a virtual keyboard via remote faster than I can input T9 text. I’m unaware of any stock remote for a device with a full keyboard. I would argue Apple has text entry perfected at least as well as any other major manufacturer. You have virtual keyboard entry, solid voice-to-text, and it can be configured to push a notification to your iOS device when you enter a search bar which will auto-open to the remote app and pull up the keyboard. Because of this feature passwords can also be autofilled from Keychain to make logins easier.

  You may personally prefer T9, but I’ve never seen anyone in the last decade input anything into a TV via T9. And you’re asking why it doesn’t have voice input, when it does. You admit to having never used an Apple TV yourself. I hate the idea of app-only interfaces features, but this isn’t a case like that. Maybe you should understand the features of a product before you call it “fucking stupid”.

• ⁨Comment⁩ on ⁨TailScale, reverse VPN, or something else to make Kavita available remotely?⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  You’ll have to strike a balance between security and ease. Your two major options are reverse proxy and VPN (Tailscale is one option for VPN)

  For reverse proxy, you functionally open the app to the internet. Anyone with the correct web address can access the login page. This is inherently less secure than VPN, but not irresponsibly so. Beyond the reverse proxy itself, you’ll also have to learn how to configure an HTTPS certificate to increase security since it will be open to the internet.

  For VPN, every user you want to be able to access the service has to be tied into the VPN and have the VPN running throughout their access. Tailscale is arguably the easiest way to configure a VPN right now, as you won’t have to manually deal with VPN configuration files for every device. VPN use will functionally make it like you’re on your home network. VPN access to your network should not be given to tons of people if at all possible.

• ⁨Comment⁩ on ⁨YSK: Do You Really Need That Antibiotic? It’s antibiotic season. Brush up on how you should use them — and when to avoid them. (NYT, Dec 2023)⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  I would like to point out, the NYT is a reputable news site but cannot even remotely be trusted with medical information/recommendations. I can’t tell you the last time I read a medical news piece from any source (and the NYT is the primary place I get my news) that I couldn’t read it and say “well that’s a gross oversimplification” or worse “this is blatantly misrepresenting the scientific author’s conclusions”. Holding up the NYT as a source of medical/scientific truth is just demonstrating how scientifically illiterate you really are.

• ⁨Comment⁩ on ⁨YSK: Do You Really Need That Antibiotic? It’s antibiotic season. Brush up on how you should use them — and when to avoid them. (NYT, Dec 2023)⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  You’re citing forum posts to discussions (with some evidence mentioned within) to support this supposition that doctors are horribly informed and out of date. But I’d like to point out that this is being vastly overblown, and even a 5-10 year out-of-date medical professional has immensely more knowledge and safe ability to recommend therapy than a layperson. I can’t pretend to know the credentials of the individual you’re responding to, but they’re clearly well versed in clinical infectious disease based on their comments, and you’re not supporting your position by citing a forum instead of the actual primary literature that supports your position.

• ⁨Comment⁩ on ⁨YSK: Do You Really Need That Antibiotic? It’s antibiotic season. Brush up on how you should use them — and when to avoid them. (NYT, Dec 2023)⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  Section 2, first paragraph. www.ncbi.nlm.nih.gov/pmc/articles/PMC6956183/

  At their core phages are viruses, there is no reason to expect the host immune system to not recognize them as foreign and attempt to eradicate them outside the GI tract, where most serious infections occur. The GI tract, skin, and to some extent the lower UG tract will likely tolerate these through mechanisms we tolerate colonizing bacterial flora, but colonization, even with antibiotic resistant organisms, is not a primary indication for empiric treatment for eradication. In fact there are some studies that attempting to sterilize the UG tract in colonized asymptomatic women promote symptomatic UTI.

  These colonizations become problematic when growth becomes unchecked and infection develops, or they seed infection into another compartment. There is no reason to think something as foreign as a bacteriophage wouldn’t be recognized as foreign in a sterile space (kidneys for pyelonephritis, liver abscess from migrated gut flora, endocarditis, etc) where these serious infections occur.

• ⁨Comment⁩ on ⁨YSK: Do You Really Need That Antibiotic? It’s antibiotic season. Brush up on how you should use them — and when to avoid them. (NYT, Dec 2023)⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  Yup, it’s hard to have a good discussion about the changing tides in ID without feeling like you’re causing a bunch of backsliding and non-compliance. I think being honest with people that the data is generally poor about how we select durations is the moral thing to do. But I do want you to just take your damn antibiotics as prescribed instead of going rouge because you heard “shorter is better” and your pneumonia recurring.

• ⁨Comment⁩ on ⁨YSK: Do You Really Need That Antibiotic? It’s antibiotic season. Brush up on how you should use them — and when to avoid them. (NYT, Dec 2023)⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  Yes, it covers intestinal colonization with MRSA. Unfortunately Staph aureus is an uncommon GI pathogen, and the majority of detrimental infections secondary to MRSA come from skin-flora translocation to produce surgical site infections/blood stream infections, as well as translocation from the nares into the lungs to produce pneumonia. We thankfully have another method of nares decolonization. While metallobetalactamase producing Pseudomonas is mentioned as well, I have a very low suspicion that FMT would be useful for resistant Pseudomonal pneumonia or diabetic foot infections/osteomyelitis. FMT certainly has a role to play in ID, particularly for enteric gram negatives and VRE within the alimentary canal, but is not a cure-all for antimicrobial resistance.

• ⁨Comment⁩ on ⁨YSK: Do You Really Need That Antibiotic? It’s antibiotic season. Brush up on how you should use them — and when to avoid them. (NYT, Dec 2023)⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  Hello all, I’m a pharmacist and 4th year medical student with a passion for antimicrobial stewardship and infectious disease. Just wanted to share my overall thoughts on the article.

  The author’s point of “finding out if you really need an antibiotic” is honestly one of the central issues in modern antimicrobial resistance coming from two fronts: patients who demand an antimicrobial for a non-indicated reason, and doctors who for various reasons excessively prescribe antibiotics. I could wax on this for hours, but at its core, the single most important thing we can do to decrease antimicrobial resistance is decreasing total antimicrobial exposure. That means fewer prescriptions for shorter courses of narrow-spectrum antibiotics. Unfortunately every bit of this requires more buy-in from patients and more work from clinicians.

  To go along with my point above, asking your doctor to make sure you’re getting the shortest possible duration is the single best thing you as a patient can do to help with these issues (other than just not demanding antibiotics if your doctor says no, but that’s a low bar). The key word here is ask though. There’s a huge amount of clinical experience and evidence that is used to determine when it is safe to stop antibiotics. And as much as I believe in patient autonomy and educating my patients, frankly antibiotic selection/course duration is not something the general public is capable of independently making decision on. Ask your doctor, and take what they prescribe for how long they’re prescribed for, and if you have issues then call them to discuss it.

  With regards to probiotics, it’s an interesting topic that we don’t have a ton of great data for and physicians are fervently behind or against them in my experience. The fact is we just don’t know enough about them, and most aren’t regulated well enough to give good information about them. Interestingly, there was a recent study which suggested higher rates of central line infections with the organisms in the probiotics in individuals given probiotics while they had a line in place.

  Lastly, I think I have to disagree with Dr. Blaser. Medicine doesn’t overvalue antibiotics. We certainly underestimate their risks, but antibiotics are some of the most effective and life-saving medications we as a species have ever developed. Countless lives have been saved solely from their development, and very very few therapies have a NNT as low as appropriate antimicrobial therapy. They truly are astonishingly good medications when they are indicated. The issue is simply prescribing them when they aren’t indicated, which is a big part of why we’re in the mess we’re in, and is in large part driven by underestimating the risks they pose.

• ⁨Comment⁩ on ⁨YSK: Do You Really Need That Antibiotic? It’s antibiotic season. Brush up on how you should use them — and when to avoid them. (NYT, Dec 2023)⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  The trouble is that, as a whole, antibiotics that work against resistant organisms are inherently more broad. Bacteria develop resistance by either mutating the target site of an antibiotic, decreasing/removing the expression of a target site, increasing removal of the drug from the bacterial cell, or preventing entrance to the cell.

  These changes are relatively antibiotic agnostic (in the sense that they do not target one specific antibiotic, they target a general chemical structure which is shared among a class of antibiotics), and in most cases, if you develop a drug which is able to circumvent one of these problems, it will continue to work on the wild-type bacteria of that species (by definition making it broader). I am unaware of any antimicrobial which is effective against drug-resistant organism which has no efficacy against the wild-type of that organism.

  I agree with the other poster that phage therapy likely represents a future avenue for antimicrobial resistance. Unfortunately antibiotics will (at least for the foreseeable future) be required as to effectively use phage therapy you must identify the organism and then select appropriate phages which will kill the bacteria, which takes time that a sick patient may not have without antibiotics. We also haven’t quite figured out how to keep our immune system from eradicating the bacteriophages, particularly for infections requiring longer treatment such as endocarditis.

  There is a currently existing technology which allows for genetic identification of bacteria and fungi in positive blood cultures approximately 1 day faster than classical methods of culture and biochemical testing. There is active research into changing these tests slightly to be able to function on other body fluids (pus, pulmonary secretions, urine, etc) as well as to be able to function on fresh blood samples instead of waiting 1-2 days for the culture to become positive from bacterial growth, but these technologies are not ready for clinical use, and until they are, broad spectrum antibiotics will be a necessity.

• ⁨Comment⁩ on ⁨YSK: Do You Really Need That Antibiotic? It’s antibiotic season. Brush up on how you should use them — and when to avoid them. (NYT, Dec 2023)⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  That’s not exactly true. FMT isn’t going to fix your MRSA colonization, and it doesn’t inherently remove resistance genes from the population of bacteria in your gut. If those genes produce a survival disadvantage, they may be selected against and become a minor serotype in your GI tract, but that doesn’t mean that it is eradicated.

  Also, you seem to be sharing a lot of links from humanmicrobiome.info, which I would advise against. While I can appreciate the primary author’s dedication to the topic and willingness to cite his sources, his website is not peer reviewed, and he explicitly states he is a proponent of FMT, introducing bias which is not being balanced by a peer review process. Not to mention he admits he is a layperson with no formal medical training/experience. I would direct you to IDSociety.org which is the home of the Infectious Disease Society of America, who publishes the actual guidelines used by infectious disease physicians in North America.

• ⁨Comment⁩ on ⁨YSK: Do You Really Need That Antibiotic? It’s antibiotic season. Brush up on how you should use them — and when to avoid them. (NYT, Dec 2023)⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  tl;dr - Asking your doctor for the shortest reasonable course is a good thing that will both protect you as a patient as well as minimize your risk of antimicrobial resistance. But the key phrase is ask your doctor, do not take it upon yourself to decide when to stop them. Take whatever course you’re prescribed.

  Pharmacist and 4th year medical student with a passion for antimicrobial stewardship and infectious disease.

  Historical treatment duration for most infections was truly quite arbitrary. Evidence for most infections, when it is actually tested, have pretty consistently demonstrated shorter treatment durations than were classically taught (10-14 days for pneumonia now generally 5-7, 14 days for Gram Negative Bacteremia now 7, etc). There is a subset of infectious disease doctors that are bucking the trend of historical “you have to complete your course advice” for some infections. In general, what I have seen is recommendations to discontinue antibiotics with significant clinical improvement AND a non-life-threatening infection in a non-sterile body cavity. So nobody is shortening course durations for empyemas or endocarditis.

  The issue becomes expecting patients to know what constitutes clinically meaningful recovery and whether or not their infection is one of the “safe” ones to stop antibiotics earlier.

  At the end of the day, I totally disagree with your premise, as we should always strive for the minimum safe antimicrobial exposure. However I do agree that telling patients “shorter is better” is bad advice because I don’t want laypeople making these decisions when usually no-ID physicians don’t make them.

• ⁨Comment⁩ on ⁨Need help getting my dad to play Baldur's Gate 3⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  IIRC I’ve never given Valve/Steam payment info. Everything is processed through PayPal. But even then, you should be able to gift his account a purchase without him putting in payment methods if you can convince him to use steam at all

• ⁨Comment⁩ on ⁨It's official: Evernote will restrict free users to 50 notes | TechCrunch⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  I self host a lot of shit, but after almost a year of using Obsidian I finally paid for their sync feature for one reason: iCloud sync to iOS is painfully slow.

  I was sometimes waiting 30-45 seconds to jot down a note just waiting on the app to open with iCloud sync as my backend. Now, with Obsidian sync, the app is ready-to-go in seconds.

  Now if you’re only going to be using on desktop, I would definitely consider a git-repository based sync, but if you’re gonna use mobile I’d recommend you at least consider Obsidian Sync

• ⁨Comment⁩ on ⁨The History and Future of Digital Ownership⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  Yes, but most DRM has been circumvented in one way or another. DRM primarily continues to keep law-abiding citizens from easily acquiring a copy of media they rightfully own as opposed to preventing piracy.

  Though if institutions insist on utilizing DRM for prevention of privacy, I do think that DRM should be built to fail after a meaningful timeframe, at worst the expiry of the copyright for the material. Unfortunately many pieces of media, particularly video games, are abandoned and unsupported long before their copywriter expires. Abandonware in general is not well handled by modern copywrite law.

• ⁨Comment⁩ on ⁨The History and Future of Digital Ownership⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  I think the point is more so why are digital purchased DRM’ed and prohibited from local storage in so many ways. The historical argument is “well you’re not buying it, you’re buying a license to use it for as long as we wish to provide it”, but why does it necessarily need to be that way. And more generally, from the standpoint of artistic/media preservation, as BluRay releases continue to decrease and console video game releases become continually more digital-only, these non-archivable or locked-without-server-license-validation media results in IP that at some point in time, this media could be permanently lost.

  Personally, I feel this is unacceptable. The media we consume forms a huge portion of our culture, and is just as much an example of artistic expression as painting. While I thoroughly believe artists/companies should be able to charge for these properties, I do not believe that when it is no longer profitable for them to support the system, that these pieces of media should simply be discarded with no method for future recovery and preservation.

• ⁨Comment⁩ on ⁨Drugmakers Are Set to Pay 23andMe Millions to Access Consumer DNA⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  That’s not true. HIPAA covers anyone handling protected health information in a professional manner. If some office clerk at the VA is mailing out copies of HIPAA-protected information, they’re bound by HIPAA. If a consulting IT firm has access to a hospital’s servers as they’re changing something about the EHR, they’re bound by HIPAA. Protected information cannot make its way from a “covered entity” to a non-covered entity like a totally unrelated bakery who would not have an obligation to protect your information without either: 1) violating the law, 2) you personally disclosing the information to the non-protected party, or 3) you or someone authorized on your behalf signing a disclosure waiver permitting the covered entity to disclose

• ⁨Comment⁩ on ⁨[deleted]⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  Could you elaborate on what you mean?