I would have misgivings of using the character with René, but it wouldn’t be hard. He’s changeling, god dammit. It was one of the weird conceits of DS9 that odo kept the same humanoid form, and so the changeling who interacted with him did too (along with implausible excuses about “not being able to master the humanoid face”, or the changing virus).

Having spent time with the founders, you could easily recast “Odo” as a dozen different characters of different species and genders. Perhaps he has transcended the attachment to a single form that he developed from living among solids? I feel like watching some good actors do Odoesque performances could be quite interesting!