Stands for Trump Derangement Syndrome. I first learned of it when Rob Reiner and his wife were murdered by their son, and Trump blamed their deaths on TDS Just a part of Trump’s insane post referencing it below: > Rob Reiner … has passed away, together with his wife, Michele, reportedly due to the anger he caused others through his massive, unyielding, and incurable affliction with a mind crippling disease known as TRUMP DERANGEMENT SYNDROME, sometimes referred to as TDS. He was known to have driven people CRAZY by his raging obsession of President Donald J. Trump … Source, if you want to read the whole crazy post.