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Comment on YSK that designer psychedelics are a thing now apparently

I’m not going to look at the Xitter thread, because fuck fascists, and fuck Elon. If you have other non-fashy sources, I’d be happy to look at them. Real research has papers, not Xitter threads, and Dillan DiNardo is a venture capitalist with a company trying to develop and sell designer drugs. Not exactly an unbiased source.

For the other links, the first is showing the antianxiety potential of the substance DOI and how scientists were able to document the mechanisms of its effects better (which leads to the possibility of targeted drugs). The second is about a new drug, dubbed JRT, that is able to harness neuroplastic effects without hallucinogenic ones; they’re targeting schizophrenia, which is good news for anyone that suffers.

Maybe the wealthy will be able to pay for their own custom molecules, but I am skeptical that bespoke psychedelics are on the horizon (at least for average people).

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confuser@lemmy.zip ⁨1⁩ ⁨week⁩ ago
wired.com/…/a-startup-used-ai-to-make-a-psychedel…

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- Telorand@reddthat.com ⁨1⁩ ⁨week⁩ ago
  I don’t know what other data they have, but Mindstate’s Phase 1 trial size was only 47, and how effective it was wasn’t actually documented in the article (other than vague “it was safe and well-tolerated” language). It’s obviously not poison, but whether it actually treated anything is still an open question, and how effective it will be for people in general is another; they’re aiming for the FDA to approve the drug on it’s own, and just producing a neuroplastic mental state may not be enough without guided therapy.
  
  I sincerely hope for a drug that’s effective at treating various mental disorders, but the funding on this is practically the “who’s who” of Conservative/billionaire ghouls:
  
  Founded in 2021 and backed by Y Combinator and the founders of OpenAI, Neuralink, Instacart, Coinbase, and Twitch, Mindstate has built a set of AI models that connect biochemical data from different psychactive drugs to more than 70,000 “trip reports” compiled from a variety of sources—from official clinical trial datasets and drug forums to social media, Reddit, and even the dark web.
  
  Behold the new faces of Big Pharma. These aren’t the sort to do things for the benefit of humanity. It might turn out that this is exactly what is promised on the tin, but I will be surprised if this is not gated by a steep price tag.
  
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  - confuser@lemmy.zip ⁨1⁩ ⁨week⁩ ago
    yeah I wouldn’t expect a new thing to immediately out of the gate be a magic bullet but this existing at all is pretty mind blowing and the future is gonna have some cool things
    
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    Telorand@reddthat.com ⁨1⁩ ⁨week⁩ ago
    The science is certainly interesting. It is disheartening who is behind it, however.
    
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