Comment on The FDA Is Approving Drugs Without Evidence They Work

• notfromhere@lemmy.ml ⁨2⁩ ⁨days⁩ ago

  Is that what killed the brainworm? Fuck

  source

  • sp3ctr4l@lemmy.dbzer0.com ⁨2⁩ ⁨days⁩ ago

    … somewhat ironically, it is at least barely, slightly plausible that ivermectin could have taken out the brain worm…

    it is an actual anti-parasitic, but uh… its only been tested and approved as an anti-parasitic for humans via oral ingestion…

    … but it is intravenously administered to cows and pigs as an anti-parasitic.

    So… IV ivermectin in a human could potentially work, but … good luck figuring out the right dosage, and hopefully human bio chemistry and blood brain barrier just function identically as within pigs and cows.

    I am not a medical expert, but I suspect that latter part just maybe might not be a great assumption.

    source

    • Revan343@lemmy.ca ⁨2⁩ ⁨days⁩ ago

      Generally if it’s effective orally, it’ll be effective intravenously, so I would expect it to work…the issue with dosage is more likely to be in the opposite direction, with significant side effects due to overdosing.

      One concern is neurotoxicity after large overdoses, which in most mammalian species may manifest as central nervous system depression,[58] ataxia, coma, and death

      I suppose if you overdose hard enough, it would cure COVID in addition to the brain worm

      source

      • sp3ctr4l@lemmy.dbzer0.com ⁨2⁩ ⁨days⁩ ago

        the issue with dosage is more likely to be in the opposite direction, with significant side effects due to overdosing.

        Yes, I wasn’t clear enough about it, but that is what I would be worried about, lol.

        Its… probably not just as simple as a direct proportion between cow weight:cow cow dose to human weight:human dose… as … humans are not cows.

        I suppose if you overdose hard enough, it would cure COVID in addition to the brain worm

        I remember reading hermancainaward posts about idiots who did actually take waaay too much oral (or in some cases, suppository…) ivermectin…

        So now they’re on a ventilator from the covid, and also uncontrollably shitting themselves and massively dehydrated.

        Can’t say I remember a case of ivermectin OD leading to CNS shutdown… but yeah.

        Covid skeptic/deniers were and still are astoundingly, lethally, suicidally stupid.

        source
    • Zink@programming.dev ⁨1⁩ ⁨day⁩ ago

      its only been tested and approved as an anti-parasitic for humans via oral ingestion

      Ooh, I get to do an ACKSHUALLY here. They do have it for topical treatments too, like for rosacea.

      www.drugs.com/soolantra.html

      source