Update after trying to use the site for a bit:

It seems like something got messed up. My mobile apps can’t connect to ani.social any longer and the alternative frontends are throwing 500 errors. Meanwhile, in Firefox, I am getting prompted occasionally by cloudflare to verify that I am a human.

I am guessing that some cloudflare setting is causing it to block certain consumers of the api. Federation still seems to be working, so ActivityPub is alive and well. Similarly, I was able to connect via @rikka@ani.social, so she should still be ok. However, I am getting 403’s most other ways to connect to the site.