BroccoliFarts

@BroccoliFarts@lemmy.world

• ⁨Comment⁩ on ⁨New Vaccine Can Completely Reverse Autoimmune Diseases Like Multiple Sclerosis, Type 1 Diabetes, and Crohn’s Disease⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  I work in clinical (and preclinical) trials. And I have celiac disease. I’m hopeful but not optimistic that I’ll be able to eat pasta within the next decade.

• ⁨Comment⁩ on ⁨New Vaccine Can Completely Reverse Autoimmune Diseases Like Multiple Sclerosis, Type 1 Diabetes, and Crohn’s Disease⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  There are immunotherapy treatments for cancer already. Infections and cancer use the immune system the correct way: “tag” the problem cell/virus part with an antibody, make a lot more antibody and flood your body with it to clear the problem cell/virus.

  This is the process a vaccine uses. The old vaccine method is to take a bunch of dead bacteria or inactivated virus and put that in your body. Your body should identify it and begin making antibodies against it. If you do get exposed to the disease, your body is full of antibodies which can immediately clear it, rather than letting the infection/cancer work for a few days without much of an immune response.

  An autoimmune disease, a body “tags” its own cells. Then the immune system invades the person’s own tissue.

  I have celiac disease. If I eat gluten, the enzymes I use to digest gluten become tagged. Unfortunately, humans make one gluten enzyme (TG2) that’s found everywhere in the body. A third of celiacs will have their thyroid tissue affected if they consume gluten.

  One particular antibody, IgE, is known for extreme reactions to antigens. These are the ones known for the immediate and life-threatening allergies (peanuts, shellfish, bees, wheat).

  This new stuff appears to be a way to tag antibodies or antigens or memory T cells (they hold the “blueprints” to make antibodies really quickly after your natural antibodies go away) and have the immune system “re-evaluate” the antigen. I’m guessing from the post above and a little of the article. I haven’t heard of this process in the body before.

  Cancer itself is not autoimmune (autoimmune inflammation can make it more likely to happen, but tumors don’t form directly through autoimmune mechanisms). So the first pathway used for normal vaccination is what’s needed. The difficulty lies in knowing something in each specific cancer that would make a good antibody target. It is a person’s own cells and DNA, so a lot of care has to be taken to find an appropriate antigen. Immunotherapy treatments that exist are really specific to certain types of cancer. They have much less severe side effects than radiotherapy and chemotherapy.

• ⁨Comment⁩ on ⁨Apple 15 relegated to USB 2.0 unless you buy the Pro⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  Yeah I have a Thinkpad Carbon X1. It has soldered on RAM.

• ⁨Comment⁩ on ⁨Some Tesla engineers secretly started designing a Cybertruck alternative because they 'hated' it⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  The US laws on bumpers has been refined in blood over the years. At least 20% of the people I know in my area have damaged their car by hitting a deer.

  How will this truck fare if hitting a 90 kg deer? It’s different enough that it might be substantially different (better or worse) than a more conventional truck.

  I’m also reminded of a famous car made of paneled stainless steel. It was a terrible car and ruined the company that made it. It’s only remembered fondly because of a popular movie series.

• ⁨Comment⁩ on ⁨Some Tesla engineers secretly started designing a Cybertruck alternative because they 'hated' it⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  I don’t like Musk, and I’m not a fan of Tesla in general, but I kind of dig the design. Completely understand why it’s controversial and how others could perceive it as ugly, but I like it.

  Then again, I liked the PT Cruiser when it came out (compared to all the other cars of the era), but within a year it became the car that was falling apart and owners hated it, and within 5 years it looked really dated.

  I still like the Chevy HHR and Plymouth Prowler designs. They are truly “bold” designs in that they make decisions that a large percentage of people disliked. Not the marketing “bold design” which means “we slightly exaggerated a popular design feature that’s in style right now so no one will object to it”.

• ⁨Comment⁩ on ⁨Twitter is throttling traffic to websites Elon dislikes⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  It’s an older platform that no longer exists. You’re thinking of X. Which is newer than Mastodon but still hasn’t implemented activitypub.

• ⁨Comment⁩ on ⁨Twitter is throttling traffic to websites Elon dislikes⁩ ⁨⁨1⁩ ⁨year⁩ ago⁩:

  My utility company uses Twitter, and keeps it updated with better information than they do via text message alerts. I wish they would get a mastodon account. During tornado season or ice storms, it’s nice to know if power will be back on in an hour or in three days. And once the boil water notice appeared on Twitter a couple of hours before being sent out by text.