jesse no!

Comments

• A_Very_Big_Fan@lemmy.world ⁨9⁩ ⁨hours⁩ ago

  Anyone with the relevant knowledge wanna explain what I just read?

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  • snoons@lemmy.ca ⁨5⁩ ⁨hours⁩ ago

    All I can tell you is GSK3 is a regulatory enzyme that’s involved in gene expression (people have a higher tendency for bipolar disorder if it’s inactive). IIRC it also helps to activate/inactivate Glycogen Synthase (which inactivates/activates Phosphorylase) when people are at rest/moving (respectively).

    Glycogen is a sugar molecule that muscles use to store energy; glycogen synthase creates it and phosphorylase breaks it down to glucose which is released into the blood. It wouldn’t be good to have both of them active at the same time, so there’s probably tens of kilograms of protein (enzymes) in ones body that makes sure that it doesn’t happen.

    A consensus sequence is a DNA thing that I’m not too familiar with yet but to have consensus means tho amino acid residues you’ve found match your target, whatever it is, I think? ¯\_(ツ)_/¯

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• dylanmorgan@slrpnk.net ⁨7⁩ ⁨hours⁩ ago

  He should be yelling at Hank, not Jesse. This renders your argument invalid.

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  • snoons@lemmy.ca ⁨6⁩ ⁨hours⁩ ago

    HAAAAANNNKK!!! HAAAANNNKK!!

    YOU HAVE TO CONSIDER THAT GLYCOGEN SYNTHASE KINASE 3 PHOSPHORYLATED AT ITS N-TERMINAL SERINE (Ser-21 for GSK-3α, Ser-9 for GSK-3β) IS STILL ABLE TO ACTIVELY PHOSPHORYLATE IT’S NON-PRIMED SUBSTRATES! READ SUZUKI ET AL 2013, HAAAAAANNNKKKK!!! YOUR PUTATIVE TARGET SITE IS NOT A (S/T)-X-X-X-(S/T) CONSENSUS SEQUENCE, YOU

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