I’ve been using TrueNas with a nightly sync to Backblaze for years and I like it.

It used to be called FreeNas and used FreeBSD. Now the BSD version is called TrueNas Core, and a new Linux based version is called TrueNas Scale.

I would go with TrueNas Scale if I were starting a new one today. You probably won’t use the “jail” functionality immediately, but they’re super handy, and down the line if you start playing with them, you’ll run into fewer compatibility issues running Linux vs BSD.