I currently run it in Kubernetes but I just translated my existing Docker setup to it. I recommend setting up PostgreSQL and Redis if you can for the best performance, but SQLite and no-cache-approach is also fine for the beginning (you just run a single container).

That being said, I think Nextcloud is not very cloud-native. I set up Redis just so I can do rolling updates with zero downtime (filesystem locks are kept in Redis’ memory instead of the app’s own), but I still get some server errors for a brief moment during updates (for less than 10 seconds).