I’m probably not the beat person to answer to you about the technical aspect and I’m not sure if I fully understand your question.

However I can tell you that there is no need to change anything at network level for tailscale to work.

I’ve installed and used tailscale on desktops, VM, raspberry, NAS or smartphone on plenty of different network, I’ve also remotely guided people to install tailscale on their machine at home and it always just worked. No issue at all and nothing to change on the network for it to work.