I haven’t tested these, but for ideation:

• Use the worst weapon through the game
• Do not use stat points through the game
• Only stealth
• Only guns blazing
• Sleep when it’s night (unless you’re night owl but then sleep during the day)
• Do chores in the game that a human needs to do in real life (spend time in the bathroom, pretend to shower, take a walk outside etc)
• Choose, do you handle the character’s movement or attacking. A friend/spouse does the other option
• Take off some extra brightness
• No potions/boosters
• No fast traveling