Mainboard and psu are the ones to take care the most but keep in mind that not all filament like to be printed in fully closed enclosure (without proper ventilation), PLA for exemple.

One way to monitor and secure my printer is to use smart devices. I have home assistant running at home, my printer has an integration available and i can recover several printer informations like status, temps, printing time… and i have several smart devices (mostly zigbee) which i use to monitor and apply automation based on scenarios. (temperature sensor, smoke detector, camera, light, plug to power on/off printer). I can then create automation like “when smoke detector has detected smoke, turn off printer, then send picture to my phone and broadcast a message in the house…”. I have maybe 5 different automation running for the printer but the possibilities are endless.