I use Cura 5.4 and the only changes I made were to the start and end gcode for the machine (per the guild I linked). After that, I did a few prints with my regular profiles, then started cranking up the speed a little at a time. So really the only setting I changed was the print speed and start / end gcode.

The printer handled everything else - honestly it feels a little like magic to me, even though it’s just software. I’m a software engineer so I feel like I should have a better grasp of it, but printer firmware is pretty far outside of the type of work I do. One thing I do know is that Klipper manages acceleration itself and doesn’t use the acceleration gcodes sent from the slicer - those get ignored and Klipper decides how fast to accelerate (this is configurable using moonraker or the config files).

I think the thing that makes the most difference in letting you print at higher speeds is the input shaping. I don’t understand all the inner workings, but it using the processing power on the raspberry pi to compensate for the vibration of the printer, letting you print much faster without getting artifacts in the print that affect quality. Here is some info on that

I’m sure there are a lot of slicer and Klipper configurations that I can do to improve things even more as well