Take Duelling skill. Melee is effective, you save on bullets, and when you do need to shoot someone, you absolutely can.

I’m seriously thinking of doing a mainly physical build. Maximum hand-to-hand tanky-ness. (I’m thinking “File Not Found” and play her like River Tam in Firefly). It could be fun to spend the start of the game hunting and scavenging outside of New Atlantis.