Hey, you basically defined my system.

Truenas scale machine running 4x 16TB drives. I use a cheap rosewill 4u server rack case. It has hot swap drive bays in front. Big plus.

The brain is an amd 5950x running on an asrock x570 steel legend w/ 128GB of the cheapest crucial DDR4 ECC I could find. Also running an rtx 2080 for jellyfin transcoding.

My consumer mobo is the bottleneck. Given how my end goal is to have a 10gb nic and an LSI card for more sata ports, I’m going to have to get creative with m.2 ports. I might plug a 10gb nic into an m.2 port.

PSU was a 1kW fractal platinum rated. Way overkill, but the high efficiency is key.

You’ll notice my build uses a lot of gaming parts - i simply harvested my old parts when I upgraded my gaming PC. Despite this, it still idles under 200 watts. My point is not that you should seek out gaming parts, but if you happen to have any on hand, they could be effectively leveraged given price increases on new parts.

The biggest thing is: Use ECC. This is non negotiable for your setup. ECC saved me a couple weeks ago when my 5950x shot craps, randomly. So far no issues after increasing to a set voltage. ZFS and ECC go together like peas in a pod.