As a mechanical game sts(1+2) is superior to inscryption, however do not expect any kind of narrative driven gameplay, gameplay element changes, or real interaction with the opposite side other than fighting.

I really really enjoyed inscryption, but I only played it through once. I currently have around 20 hours in sts2 and I have no idea how much in 1.

All of that being said, I do think that you can get the feel of a puzzler from slay the spire, at least in its most intense moments. Trying to find the right solution to survive. If you enjoyed the card based elements of inscryption, you will enjoy slay the spire.

Also, just skip to 2 instead of playing one. If you have any friends that like the series, try the coop too! It’s really fun and well done.