Perhaps Spacebar is a thing (the client of choice would be Fermi I think). Didn’t try it myself yet though, I do not know about how well its security protocol works. I’d assume it uses just a standard TURNS server for audio and video though.

Then of course there’s Matrix with Jitsi plugin, which will give you persistent headaches and a new appreciation of touching grass. It’s a mess, but hypothetically offers E2EE (if it works).