Yup, Adobe and Microsoft def a no-go. Especially Outlook.

For MS, the o365 web apps work as fine as they do on windows. Outlook is nearly at parity with the windows app. (I think they’re slowly making the windows apps web under the hood)

Adobe has to be pre creativecloud

You can run a windows VM, then use remote-desktop but it completely defeats the purpose unless you’re just trying to edge into privacy.