Probably April Ryan from the Longest Journey. She was clever, empathetic, funny, and well grounded. She certainly had more than enough opportunity to get annoying over the many, many hours it takes to play that game but I think I could only call her somewhat bland at points. I found myself reading the journal that served as a story tracker just to see what she had to say about what had happened. I genuinely missed her during Dreamfall. Though I had a few other favorite games with female protagonists that I loved (like Rynn from Drakan), it says something that decades later I still remember April’s name, and major character traits.