Yes they do. A big part of it is their size / capacity. Per passenger or per kg cargo they’re pretty efficient, but that doesn’t change the fact that they burn ~280,000 liters on a typical (Washington D.C. to Frankfurt) Atlantic crossing round trip.

Yes, overstated - it’s a two way Atlantic crossing. And if you consider Newfoundland to Ireland to be “an Atlantic crossing” that certainly uses less, and it’s rounded up a bit - though with unfavorable wind conditions it can exceed 300,000 liters.