Kingdom Come: Deliverance II did this really well just this year. Largely a story about contrasting a desire for adventure with the horrors and realities of war, it also has quests that are full of comedy. You can try to attract a pack of wolves using what the shepherd refers to as his absolute dumbest sheep; you can get blackout drunk with a band of mercenaries who may or may not have killed your childhood friends; you can clean up and decorate a crypt full of loose bones for a man who speaks only in rhymes, poorly, and might be a ghost.