Yes!

Unfortunately, audio through the 3.5mm jack only works if you power on the console with headphones already plugged in.

Also, the setup is opinionated. For example, it stores save games alongside ROMs, while I use the default emulation directories on my PC. This makes syncing saves more difficult and it’s not something you can disable in the emulator setting, they hardcode these directories via scrips.

Lastly, the idle battery life is significantly worse, which matters to me since I prefer to put the device to sleep.