I use Proxmox because its handy to be able to use both LXC containers and full VMs. I installed it as an ISO so its built on top of Debian. There are helper scripts specific to installing Home Assistant on a VM (as well as a number of other things). And the proxmox UI comes in handy.

I have Home Assistant in a VM so I can run it on top of HAOS. Then the rest of the box is set up as an unprivileged LXC where I installed docker. I run all my *ARR apps straight on my Synology (via docker) so they have fast access to my Library volume, and everything else running on the setup I just described. Then I use Portainer to maintain my containers so I can manage both the syno and proxmox docker installs from one page.