I’m not too knowledgeable on that front but I will say that this mod pack kind of sidelines the main story content a lot. You’ll still end up doing it but I think the issue is having to do all of the story all at once and going out of your way to do it. Here I pretty much got to the point where I was just doing main quest stuff whenever I was nearby and skipping through the dialog. I put the main story off until the very end mostly. The mods create so many quests (pretty good ones btw) that I was way more interested in those anyways. You could play through this pack and barely ever touch the main story and leave plenty satisfied.

Not to mention the DLCs are actually really good and Far Harbor itself is very long. The mods also make good use of the DLCs and add to them. So yeah the main story here is a total side quest you can basically ignore if you want to. If you end it with the Fens, you only end up doing 75% of the story and skip almost all of the institute BS