As far as the rest of it, it seems to be happening with every filament I slice in Prusa slicer.

This just reminded me of an issue I was facing recently. I also use Prusa Slicer and was having a hell of a time with my prints. It turned out to be the “Arc Fitting” setting.
In Print Settings - Advanced - Slicing look for the *Arc Fitting setting. When I had it set to “Enabled: G2/3IJ” it just completely borked my prints. Just weird problems all over the place. As soon as I set that to “Disabled”, it cleaned up my prints considerably. Not sure exactly what I’m giving up there, but I do know I’m getting much better prints.