nirodhaavidya

@nirodhaavidya@lemmy.world

• ⁨Comment⁩ on ⁨Typical US worker has less than $1,000 saved for retirement, report finds⁩ ⁨⁨3⁩ ⁨days⁩ ago⁩:

  Look at big shot over here with $1000 and an expectation of retiring.

• ⁨Comment⁩ on ⁨Charter gets FCC permission to buy Cox and become largest ISP in the US⁩ ⁨⁨1⁩ ⁨week⁩ ago⁩:

  It’s not a monopoly, but it is a cartel.

• ⁨Comment⁩ on ⁨New Cancer-Killing Material Developed by Oregon State University Nanomedicine Researchers⁩ ⁨⁨2⁩ ⁨weeks⁩ ago⁩:

  ABSTRACT

  Chemodynamic therapy (CDT) is an emerging cancer treatment that employs transition metal–based nanoagents to catalyze the conversion of elevated intracellular hydrogen peroxide in malignant cells into cytotoxic hydroxyl radicals (•OH) via Fenton-like reactions. Recent developments have also introduced CDT agents that generate singlet oxygen (1O2) through the Russell mechanism. However, current nanoplatforms efficiently produce either •OH or 1O2, but not both, and often exhibit suboptimal catalytic activity, thereby limiting the sufficient production of reactive oxygen species (ROS) required for cancer eradication. This report introduces a ferrous metal–organic framework, Fe(II)-TCPP (tetrakis(4-carboxyphenyl)porphyrin), as the first nanoagent capable of simultaneously and effectively generating •OH and 1O2 through dual catalytic pathways. Its nanoneedle-like morphology increases the surface area and promotes enhanced ROS production. Cell studies demonstrated selective intracellular generation of •OH and 1O2 in cancer cells, resulting in targeted cytotoxicity while sparing non-malignant cells. Systemic administration of Fe(II)-TCPP in a breast cancer mouse model resulted in preferential tumor accumulation, robust intratumoral ROS generation, cancer eradication, and prevention of recurrence without systemic toxicity. These findings mark a foundational advance in CDT nanoagents by integrating Fenton and Russell mechanisms into a single platform, enabling the design of multifunctional catalysts with enhanced ROS output and therapeutic efficacy.

• ⁨Comment⁩ on ⁨If you had any doubts that Know-Your-Customer laws were evil, here is one very good reason: personal data of 1 BILLION people just leaked.⁩ ⁨⁨3⁩ ⁨weeks⁩ ago⁩:

  “At this scale, downstream risks include account takeovers, targeted phishing, credit fraud, SIM swaps, and long-tail privacy harms. Industry-wide, the case underlines how third-party identity vendors have become critical infrastructure and can become single points of catastrophic failure,” our team explained."

  Wouldn’t Username + Password + SIM = 2FA password reset?

• ⁨Comment⁩ on ⁨Trigger warning - This Epstein stuff is making me sick...⁩ ⁨⁨4⁩ ⁨weeks⁩ ago⁩:

  God Damned, that is pure fucking evil. Like, I can’t even… Just literal evil.

• ⁨Comment⁩ on ⁨DHS asks tech companies for names, email addresses and phone numbers of accounts that criticize ICE⁩ ⁨⁨4⁩ ⁨weeks⁩ ago⁩:

  Seconded. If true, my paranoia will be justified and prove to be woefully insufficient.

• ⁨Comment⁩ on ⁨The Death of DeviantArt and the art-site shaped hole haunting the Internet -- Multi-hyphenate⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  I miss the old days of DA. Countless hours of scrolling to find the perfect wallpaper or art for my TTRPG games. Now I mostly use Patreon or occasionally ArtStation. But it not the same.

• ⁨Comment⁩ on ⁨Give me some good ones⁩ ⁨⁨2⁩ ⁨months⁩ ago⁩:

  Every moment I spend with you is better than the next.

• ⁨Comment⁩ on ⁨Google Assistant Is Basically on Life Support and Things Just Got Worse⁩ ⁨⁨7⁩ ⁨months⁩ ago⁩:

  I assume this is going to arrive at the solution of “Upgrade to Gemini-supported devices today!” Yeah, no thanks. I wish I could get Home Assistant working with my nest minis.

• ⁨Comment⁩ on ⁨Resurrecting a dead torrent tracker and finding 3 million peers⁩ ⁨⁨8⁩ ⁨months⁩ ago⁩:

  It’s demonii ! Damn that takes me back. Wasn’t that a tracker for Demoniod? Interesting small blog post. Has screenshots of the process.