Disabling CoW for databases on btrfs is well known, but this seems to be even better for Sqlite.
Nice little fix to improve SQLite performance on Btrfs
Submitted 2 years ago by poVoq@slrpnk.net to selfhosting@slrpnk.net
https://wiki.tnonline.net/w/Blog/SQLite_Performance_on_Btrfs