To create an application that integrates ChatGPT Gratis with Python, developers need to access OpenAI’s API using Python libraries like openai or requests. These libraries allow you to send requests to ChatGPT and receive intelligent responses in return. By setting up the proper configurations and tokenization, you can ensure that ChatGPT understands and responds in Español, providing accurate and contextually relevant information. Moreover, developers can utilize Python frameworks such as Django or Flask to create web-based applications that incorporate ChatGPT. This integration helps build interactive platforms that cater to Spanish-speaking users, offering services like automated translation, language learning, or customer support systems.