I use KeePassXC and a Yubikey 5. You can store a certain number of 2fa on the key but i also back up the secret key and recovery codes on KeePassXC which is backed up on my Nextcloud. When using the Yubikey there is an app on desktop and mobile that reads they key but doesn’t store the codes. Open the app, plug in the key, the TOTP appears, take the key out and the TOTP is gone.