Qubes OS doesn’t have GPU acceleration using Virtio-powered interfaces if that’s something you need. Also it’s based on Xen and you are not encouraged to mess around with dom0.

TBH if there’s a way that you can attach to the display output of a VM with a GUI when you start your computer, it will probably fit your use-case perfectly. I haven’t found a method to do this but I think there should be some way to attach directly to the display of a VM after booting up.