I’ve done this. I was working for scraps out of college as a community reporter when an ostensibly conservative online news organization offered me an 80% pay raise and the opportunity to do most of my work from home. I was young, recently married and wanted to start a family, and we needed the money. The bigger salary was nice, but over the course of two years I spiraled into a deep depression and began to loath myself and what I did. It was so bad I began looking for a way out after the first six months. Eventually I got out (took a pay cut to do so) but am now in a much better place personally and professionally. I would never do anything like that ever again.