The language best suited for wasm is easily rust. And you can still interface with the Dom using frameworks like yew sycamore or leptos.

Debugging is still a little tricky but you can debug wasm in chrome and DWARF allows you to have source maps that map to your rust code. This is s problem the community is working to improve. Until then you have the full power of console log which is how a large portion of developers already debug their applications.